Inefficiencies in COPD Clinical Trials
Per Study Cost
Source: HHS
According to research by the U.S. Department of Health and Human Services, the therapeutic area with the highest clinical research cost is the respiratory system (source).
Underlying cost drivers in these trials include:
- Complex disease process
- Imprecise conventional endpoints
- Operational challenges
These factors drive large subject cohorts, study site complexities, and data quality issues that extend trial timelines and costs.
Data Quality
Biomarker Reliability
Reliability in quantitative CT (QCT) is determined by the consistency (or repeatability) of a measure. QCT measurement consistency (test/re-test) for 38 of VIDA’s digital imaging biomarkers was recently published in the American Journal of Respiratory and Critical Care Medicine (source). This important study showed high repeatability and reliability for QCT measures and revealed the importance of high-quality data and performing quality control (QC), which improved repeatability and reliability.
Modern Trial Imaging Management
Not all quantitative imaging data is equal.
To optimize data quality and streamline operational ease, VIDA provides a full range of trial imaging management services, built upon 20+ years of experience. These services are enabled by the VIDA Intelligence Platform, a modern AI-powered trial imaging system.
Since introduction of the innovative platform in early 2022:
*Among trials where imaging metrics are the primary endpoint.
VIDA is proud to be the lead Quantitative CT (QCT) imaging provider for SPIROMICS, a large multi-site COPD study for the purpose of identifying subpopulations and intermediate outcome measures.
More Resources
If you are interested to learn more about Quantitative Imaging Biomarkers for COPD, or our trial imaging services in general, we’d love to speak with you.
If addition, please enjoy the following programs and resources related to Clinical Trial Imaging for COPD:
COPD Studies Utilizing VIDA’s Precision Quantitative Imaging Solution
4835300
KPUFPHHZ
1
nature
50
extra
1
1
1
title
1
15868
https://vidalung.ai/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A50%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22RKFDZEGI%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chaudhary%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BChaudhary%2C%20M.%20F.%20A.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2589750022002321%26%23039%3B%26gt%3BPredicting%20severe%20chronic%20obstructive%20pulmonary%20disease%20exacerbations%20using%20quantitative%20CT%3A%20a%20retrospective%20model%20development%20and%20external%20validation%20study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BThe%20Lancet%20Digital%20Health%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B5%26lt%3B%5C%2Fb%26gt%3B%2C%20e83%5Cu2013e92%20%282023%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Predicting%20severe%20chronic%20obstructive%20pulmonary%20disease%20exacerbations%20using%20quantitative%20CT%3A%20a%20retrospective%20model%20development%20and%20external%20validation%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%20F%20A%22%2C%22lastName%22%3A%22Chaudhary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junfeng%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%20P%22%2C%22lastName%22%3A%22Comellas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D%22%2C%22lastName%22%3A%22Newell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prashant%22%2C%22lastName%22%3A%22Nagpal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Spyridon%22%2C%22lastName%22%3A%22Fortis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%20E%22%2C%22lastName%22%3A%22Christensen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20E%22%2C%22lastName%22%3A%22Gerard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yue%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Di%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fereidoun%22%2C%22lastName%22%3A%22Abtin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Igor%20Z%22%2C%22lastName%22%3A%22Barjaktarevic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Surya%20P%22%2C%22lastName%22%3A%22Bhatt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandeep%22%2C%22lastName%22%3A%22Bodduluri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20B%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Gravens-Mueller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ella%20A%22%2C%22lastName%22%3A%22Kazerooni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martha%20G%22%2C%22lastName%22%3A%22Menchaca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%20E%22%2C%22lastName%22%3A%22Ortega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20Paine%22%2C%22lastName%22%3A%22Iii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joyce%20D%22%2C%22lastName%22%3A%22Schroeder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prescott%20G%22%2C%22lastName%22%3A%22Woodruff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20M%22%2C%22lastName%22%3A%22Reinhardt%22%7D%5D%2C%22abstractNote%22%3A%22Background%20Quantitative%20CT%20is%20becoming%20increasingly%20common%20for%20the%20characterisation%20of%20lung%20disease%3B%20however%2C%20its%20added%20potential%20as%20a%20clinical%20tool%20for%20predicting%20severe%20exacerbations%20remains%20understudied.%20We%20aimed%20to%20develop%20and%20validate%20quantitative%20CT-based%20models%20for%20predicting%20severe%20chronic%20obstructive%20pulmonary%20disease%20%28COPD%29%20exacerbations.%22%2C%22date%22%3A%2202%5C%2F2023%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2589-7500%2822%2900232-1%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2589750022002321%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2225897500%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222024-02-21T22%3A40%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22TT6VUFJW%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Woodruff%20et%20al.%22%2C%22parsedDate%22%3A%222016-05-12%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BWoodruff%2C%20P.%20G.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1056%5C%2FNEJMoa1505971%26%23039%3B%26gt%3BClinical%20Significance%20of%20Symptoms%20in%20Smokers%20with%20Preserved%20Pulmonary%20Function%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BNew%20England%20Journal%20of%20Medicine%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B374%26lt%3B%5C%2Fb%26gt%3B%2C%201811%5Cu20131821%20%282016%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20Significance%20of%20Symptoms%20in%20Smokers%20with%20Preserved%20Pulmonary%20Function%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prescott%20G.%22%2C%22lastName%22%3A%22Woodruff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%22%2C%22lastName%22%3A%22Bleecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20A.%22%2C%22lastName%22%3A%22Christenson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Couper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%20L.%22%2C%22lastName%22%3A%22Curtis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%20A.%22%2C%22lastName%22%3A%22Gouskova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%20N.%22%2C%22lastName%22%3A%22Hansel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20E.%22%2C%22lastName%22%3A%22Kanner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Kleerup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20C.%22%2C%22lastName%22%3A%22Lazarus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Paine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22Rennard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donald%20P.%22%2C%22lastName%22%3A%22Tashkin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K.%22%2C%22lastName%22%3A%22Han%22%7D%5D%2C%22abstractNote%22%3A%22Although%20they%20do%20not%20meet%20the%20current%20criteria%20for%20COPD%2C%20symptomatic%20current%20or%20former%20smokers%20with%20preserved%20pulmonary%20function%20have%20exacerbations%2C%20activity%20limitation%2C%20and%20evidence%20of%20airway%20disease.%22%2C%22date%22%3A%222016-05-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1056%5C%2FNEJMoa1505971%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1056%5C%2FNEJMoa1505971%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220028-4793%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fnejm.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22KITAWLVH%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Smith%20et%20al.%22%2C%22parsedDate%22%3A%222014-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BSmith%2C%20B.%20M.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4198462%5C%2F%26%23039%3B%26gt%3BComparison%20of%20Spatially%20Matched%20Airways%20Reveals%20Thinner%20Airway%20Walls%20in%20COPD.%20The%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20%28MESA%29%20COPD%20Study%20and%20the%20Subpopulations%20and%20Intermediate%20Outcomes%20in%20COPD%20Study%20%28SPIROMICS%29%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BThorax%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B69%26lt%3B%5C%2Fb%26gt%3B%2C%20987%5Cu2013996%20%282014%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20Spatially%20Matched%20Airways%20Reveals%20Thinner%20Airway%20Walls%20in%20COPD.%20The%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20%28MESA%29%20COPD%20Study%20and%20the%20Subpopulations%20and%20Intermediate%20Outcomes%20in%20COPD%20Study%20%28SPIROMICS%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20M.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan%22%2C%22lastName%22%3A%22Rabinowitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%22%2C%22lastName%22%3A%22Bleecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Christenson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Couper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathleen%20M.%22%2C%22lastName%22%3A%22Donohue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meilan%20K.%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%20N.%22%2C%22lastName%22%3A%22Hansel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20E.%22%2C%22lastName%22%3A%22Kanner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Kleerup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22Rennard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22Airway%20walls%20are%20thinner%20in%20COPD%20when%20comparing%20spatially%20matched%20central%20airways.%22%2C%22date%22%3A%222014-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fthoraxjnl-2014-205160%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4198462%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220040-6376%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222024-04-05T18%3A00%3A00Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fthorax.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22UY7NHERI%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wang%20et%20al.%22%2C%22parsedDate%22%3A%222022-04-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BWang%2C%20J.%20M.%2C%20Ram%2C%20S.%2C%20Labaki%2C%20W.%20W.%2C%20Han%2C%20M.%20K.%20%26amp%3B%20Galb%5Cu00e1n%2C%20C.%20J.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9056100%5C%2F%26%23039%3B%26gt%3BCT-Based%20Commercial%20Software%20Applications%3A%20Improving%20Patient%20Care%20Through%20Accurate%20COPD%20Subtyping%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BInt%20J%20Chron%20Obstruct%20Pulmon%20Dis%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B17%26lt%3B%5C%2Fb%26gt%3B%2C%20919%5Cu2013930%20%282022%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22CT-Based%20Commercial%20Software%20Applications%3A%20Improving%20Patient%20Care%20Through%20Accurate%20COPD%20Subtyping%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%20M%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sundaresh%22%2C%22lastName%22%3A%22Ram%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wassim%20W%22%2C%22lastName%22%3A%22Labaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Craig%20J%22%2C%22lastName%22%3A%22Galb%5Cu00e1n%22%7D%5D%2C%22abstractNote%22%3A%22This%20article%20reviews%20the%20key%20features%20of%20several%20commercial%20platforms%2C%20including%20the%20technologies%20they%20are%20based%20on%2C%20the%20metrics%20they%20can%20generate%2C%20and%20their%20clinical%20correlations%20and%20applications.%22%2C%22date%22%3A%222022-4-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.2147%5C%2FCOPD.S334592%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9056100%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221176-9106%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222023-08-25T19%3A55%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22M452EUDZ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hammond%20et%20al.%22%2C%22parsedDate%22%3A%222017-09%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BHammond%2C%20E.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5603212%5C%2F%26%23039%3B%26gt%3BComparison%20of%20Low%20and%20Ultra-Low%20Dose%20Computed%20Tomography%20Protocols%20For%20Quantitative%20Lung%20and%20Airway%20Assessment%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BMed%20Phys%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B44%26lt%3B%5C%2Fb%26gt%3B%2C%204747%5Cu20134757%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20Low%20and%20Ultra-Low%20Dose%20Computed%20Tomography%20Protocols%20For%20Quantitative%20Lung%20and%20Airway%20Assessment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%22%2C%22lastName%22%3A%22Hammond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chelsea%22%2C%22lastName%22%3A%22Sloan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D.%22%2C%22lastName%22%3A%22Newell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jered%20P.%22%2C%22lastName%22%3A%22Sieren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Saylor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Craig%22%2C%22lastName%22%3A%22Vidal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shayna%22%2C%22lastName%22%3A%22Hogue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22De%20Stefano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Sieren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%20C.%22%2C%22lastName%22%3A%22Sieren%22%7D%5D%2C%22abstractNote%22%3A%22The%20use%20of%20IR%20with%20low%20and%20ultra-low%20dose%20CT%20protocols%20with%20CT%20volume%20dose%20indices%20down%20to%200.32%20mGy%20maintains%20selected%20quantitative%20parenchymal%20and%20airway%20measurements%20relevant%20to%20pulmonary%20disease%20characterization.%22%2C%22date%22%3A%222017-9%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fmp.12436%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5603212%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220094-2405%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22D85WNAN2%22%2C%22KPUFPHHZ%22%2C%22YRXIESTN%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22I3R6X3NV%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Motahari%20et%20al.%22%2C%22parsedDate%22%3A%222023-07-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BMotahari%2C%20A.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.atsjournals.org%5C%2Fdoi%5C%2F10.1164%5C%2Frccm.202209-1698PP%26%23039%3B%26gt%3BRepeatability%20of%20Pulmonary%20Quantitative%20CT%20Measurements%20in%20COPD%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BAm%20J%20Respir%20Crit%20Care%20Med%26lt%3B%5C%2Fi%26gt%3B%20rccm.202209-1698PP%20%282023%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1164%5C%2Frccm.202209-1698PP%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1164%5C%2Frccm.202209-1698PP%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Repeatability%20of%20Pulmonary%20Quantitative%20CT%20Measurements%20in%20COPD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amin%22%2C%22lastName%22%3A%22Motahari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wayne%20H%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Igor%22%2C%22lastName%22%3A%22Barjaktarevic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%20R%22%2C%22lastName%22%3A%22Bleecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%20P.%22%2C%22lastName%22%3A%22Comellas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20B.%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J%22%2C%22lastName%22%3A%22Couper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%20N%22%2C%22lastName%22%3A%22Hansel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20E%22%2C%22lastName%22%3A%22Kanner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ella%20A%22%2C%22lastName%22%3A%22Kazerooni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A.%22%2C%22lastName%22%3A%22Lynch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D%22%2C%22lastName%22%3A%22Newell%20Jr.%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joyce%20D.%22%2C%22lastName%22%3A%22Schroeder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20M.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prescott%20G%22%2C%22lastName%22%3A%22Woodruff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22for%20The%20SPIROMICS%20Group%22%7D%5D%2C%22abstractNote%22%3A%22Moving%20forward%2C%20it%20is%20clear%20that%20with%20careful%20selection%20of%20outcome%20measure%20and%20protocol%20design%2C%20excellent%20repeatability%20of%20QCT%20metrics%20can%20be%20achieved%2C%20on%20par%20with%20pulmonary%20function%20data%20that%20are%20currently%20widely%20accepted%20both%20in%20clinical%20practice%20and%20by%20the%20FDA.%20This%20is%20particularly%20true%20for%20density%20based%20measures.%22%2C%22date%22%3A%222023-07-25%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1164%5C%2Frccm.202209-1698PP%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.atsjournals.org%5C%2Fdoi%5C%2F10.1164%5C%2Frccm.202209-1698PP%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221073-449X%2C%201535-4970%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222023-07-27T17%3A23%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22SCMWR8ES%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Almuhanna%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BAlmuhanna%2C%20A.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpublications.ersnet.org%5C%2Fcontent%5C%2Ferj%5C%2F66%5C%2Fsuppl_69%5C%2FOA4440%26%23039%3B%26gt%3BMucus%20plugging%20is%20associated%20with%20systemic%20inflammation%20in%20COPD%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BEuropean%20Respiratory%20Journal%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B66%26lt%3B%5C%2Fb%26gt%3B%2C%20%282025%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mucus%20plugging%20is%20associated%20with%20systemic%20inflammation%20in%20COPD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdulrahman%22%2C%22lastName%22%3A%22Almuhanna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Federico%22%2C%22lastName%22%3A%22Baraldi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aaron%22%2C%22lastName%22%3A%22Braddy-Green%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mairi%22%2C%22lastName%22%3A%22Macleod%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bartlett-Pestel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordina%22%2C%22lastName%22%3A%22Mah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralph%22%2C%22lastName%22%3A%22Lopez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hassan%22%2C%22lastName%22%3A%22Shabakhti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Apolline%22%2C%22lastName%22%3A%22Marion%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Allinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jadwiga%22%2C%22lastName%22%3A%22Wedzicha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lydia%22%2C%22lastName%22%3A%22Finney%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bp%26gt%3B%26lt%3Bbold%26gt%3BBackground%3A%26lt%3B%5C%2Fbold%26gt%3B%20Mucus%20plugging%20is%20a%20radiological%20biomarker%20associated%20with%20disease%20severity%2C%20risk%20of%20exacerbations%20and%20all-cause%20mortality%20in%20COPD%20and%20a%20potential%20treatable%20trait.%20The%20relationship%20between%20mucus%20plugging%20and%20biomarkers%20of%20neutrophilic%20and%20systemic%20inflammation%20has%20not%20yet%20been%20explored.%20We%20hypothesized%20that%20mucus%20plugging%20is%20associated%20with%20increased%20blood%20neutrophil%20count%20%28BNC%29%20and%20markers%20of%20systemic%20inflammation.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3BMethodology%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3BWe%20conducted%20a%20cross-sectional%20study%20of%20the%20EXCEL%20London%20COPD%20cohort.%20Presence%20of%20mucus%20plugs%20was%20determined%20on%20CT%20thorax%20scans%20using%20a%20computer%20assisted%20scoring%20system%20%28VIDA%20Diagnostics%29.%20C-reactive%20protein%2C%20fibrinogen%20and%20full%20blood%20count%20were%20collected%20on%20the%20day%20of%20the%20CT%20scan.%20Patients%20were%20divided%20into%203%20groups%3A%20no%20mucus%20plugs%20%28A%29%2C%20mucus%20plug%20score%201%20to%202%20%28B%29%2C%20and%20mucus%20plug%20score%20%5Cu2265%202%20%28C%29.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bbold%26gt%3BResults%3A%26lt%3B%5C%2Fbold%26gt%3B%20There%20were%2081%20COPD%20participants%20included.%20BNC%20was%20significantly%20increased%20in%20patients%20with%20mucus%20plugs%20%28groups%20B%20and%20C%29%204.8x10%2A9%5C%2FL%20and%204.3x10%2A9%5C%2FL%20compared%20to%20those%20with%20no%20plugs%20%28A%29%203.6x10%2A9%5C%2FL%20%28P%3D0.024%29.%20Fibrinogen%20was%20also%20significantly%20greater%20in%20group%20B%20and%20C%203.6%20g%5C%2FL%20compared%20to%20those%20with%20no%20mucus%20plugs%20%28A%29%203.2%20g%5C%2FL%20%28P%3D0.02%29.%20Multivariate%20analysis%20found%20no%20difference%20in%20BNC%20between%20groups%20after%20adjusting%20for%20age%2C%20sex%2C%20BMI%2C%20FEV1%5C%2FFVC%20and%20exacerbation%20frequency.%20However%2C%20Fibrinogen%20remained%20increased%20in%20patients%20with%20mucus%20plugs%20%28B%20and%20C%29%20compared%20to%20no%20mucus%20plugs%20%28A%29%20following%20adjustment%20for%20multiple%20variables.%20Other%20markers%20of%20systemic%20inflammation%20were%20not%20different%20between%20groups.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bbold%26gt%3BConclusion%3A%26lt%3B%5C%2Fbold%26gt%3B%20Mucus%20plugging%20was%20associated%20with%20increased%20Fibrinogen%20and%20BNC.%20Further%20mechanistic%20studies%20are%20needed%20to%20identify%20treatments%20to%20reduce%20mucus%20plugging%20and%20improve%20outcomes.%26lt%3B%5C%2Fp%26gt%3B%22%2C%22date%22%3A%222025-11-18%22%2C%22section%22%3A%22Monitoring%20airway%20disease%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1183%5C%2F13993003.congress-2025.OA4440%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpublications.ersnet.org%5C%2Fcontent%5C%2Ferj%5C%2F66%5C%2Fsuppl_69%5C%2FOA4440%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220903-1936%2C%201399-3003%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222026-01-14T17%3A26%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22LHX6UHMJ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Armstrong%20et%20al.%22%2C%22parsedDate%22%3A%222017-02%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BArmstrong%2C%20H.%20F.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Lung%20function%2C%20percent%20emphysema%2C%20and%20QT%20duration%3A%20The%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20%28MESA%29%20lung%20study.%20%26lt%3Bi%26gt%3BRespir%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B123%26lt%3B%5C%2Fb%26gt%3B%2C%201%26%23x2013%3B7%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lung%20function%2C%20percent%20emphysema%2C%20and%20QT%20duration%3A%20The%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20%28MESA%29%20lung%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hilary%20F.%22%2C%22lastName%22%3A%22Armstrong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%20S.%22%2C%22lastName%22%3A%22Lovasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elsayed%20Z.%22%2C%22lastName%22%3A%22Soliman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%20R.%22%2C%22lastName%22%3A%22Heckbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruce%20M.%22%2C%22lastName%22%3A%22Psaty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20H.%20M.%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerry%20A.%22%2C%22lastName%22%3A%22Krishnan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Craig%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20J.%22%2C%22lastName%22%3A%22Budoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%20E.%22%2C%22lastName%22%3A%22Watson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22We%20tested%20the%20hypotheses%20that%20lower%20lung%20function%20and%20increased%20percent%20emphysema%20on%20computed%20tomography%20%28CT%29%20are%20associated%20with%20a%20prolonged%20QT%20interval%20in%20a%20general%20population%20sample%20and%20additionally%20in%20those%20with%20COPD.%22%2C%22date%22%3A%222017-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.rmed.2016.12.003%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221532-3064%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A25%3A56Z%22%7D%7D%2C%7B%22key%22%3A%2297RGMIIM%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Begum%20et%20al.%22%2C%22parsedDate%22%3A%222016-10-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBegum%2C%20F.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fjournals.plos.org%5C%2Fplosone%5C%2Farticle%3Fid%3D10.1371%5C%2Fjournal.pone.0164134%26%23039%3B%26gt%3BHemizygous%20Deletion%20on%20Chromosome%203p26.1%20Is%20Associated%20with%20Heavy%20Smoking%20among%20African%20American%20Subjects%20in%20the%20COPDGene%20Study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BPLOS%20ONE%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B11%26lt%3B%5C%2Fb%26gt%3B%2C%20e0164134%20%282016%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hemizygous%20Deletion%20on%20Chromosome%203p26.1%20Is%20Associated%20with%20Heavy%20Smoking%20among%20African%20American%20Subjects%20in%20the%20COPDGene%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ferdouse%22%2C%22lastName%22%3A%22Begum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ingo%22%2C%22lastName%22%3A%22Ruczinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20E.%22%2C%22lastName%22%3A%22Hokanson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharon%20M.%22%2C%22lastName%22%3A%22Lutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margaret%20M.%22%2C%22lastName%22%3A%22Parker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20H.%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%20B.%22%2C%22lastName%22%3A%22Hetmanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20B.%22%2C%22lastName%22%3A%22Scharpf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20D.%22%2C%22lastName%22%3A%22Crapo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edwin%20K.%22%2C%22lastName%22%3A%22Silverman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Terri%20H.%22%2C%22lastName%22%3A%22Beaty%22%7D%5D%2C%22abstractNote%22%3A%22Here%2C%20we%20included%202%2C889%20African%20American%20and%206%2C187%20non-Hispanic%20White%20subjects%20from%20the%20COPDGene%20cohort%20%28http%3A%5C%2F%5C%2Fwww.copdgene.org%29%20to%20carefully%20investigate%20the%20role%20of%20polymorphic%20CNVs%20across%20the%20genome%20on%20various%20measures%20of%20smoking%20behavior.%22%2C%22date%22%3A%22Oct%206%2C%202016%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0164134%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.plos.org%5C%2Fplosone%5C%2Farticle%3Fid%3D10.1371%5C%2Fjournal.pone.0164134%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22YRXIESTN%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A26%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22GEB7IR47%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Beiko%20et%20al.%22%2C%22parsedDate%22%3A%222017-07-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBeiko%2C%20T.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Feuropepmc.org%5C%2Farticles%5C%2FPMC5556912%26%23039%3B%26gt%3BSerum%20Proteins%20Associated%20with%20Emphysema%20Progression%20in%20Severe%20Alpha-1%20Antitrypsin%20Deficiency%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BChronic%20Obstr%20Pulm%20Dis%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B4%26lt%3B%5C%2Fb%26gt%3B%2C%20204%5Cu2013216%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Serum%20Proteins%20Associated%20with%20Emphysema%20Progression%20in%20Severe%20Alpha-1%20Antitrypsin%20Deficiency%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tatsiana%22%2C%22lastName%22%3A%22Beiko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20G%22%2C%22lastName%22%3A%22Janech%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%20V%22%2C%22lastName%22%3A%22Alekseyenko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carl%22%2C%22lastName%22%3A%22Atkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harvey%20O%22%2C%22lastName%22%3A%22Coxson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%20L%22%2C%22lastName%22%3A%22Barth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20E%22%2C%22lastName%22%3A%22Stephenson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%20L%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lynn%20M%22%2C%22lastName%22%3A%22Schnapp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alan%22%2C%22lastName%22%3A%22Barker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Brantly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20A%22%2C%22lastName%22%3A%22Sandhaus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edwin%20K%22%2C%22lastName%22%3A%22Silverman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20K%22%2C%22lastName%22%3A%22Stoller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruce%22%2C%22lastName%22%3A%22Trapnell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Strange%22%2C%22lastName%22%3A%22Charlie%22%7D%5D%2C%22abstractNote%22%3A%22We%20investigated%20whether%20distinct%20proteomic%20signatures%20characterize%20the%20presence%20and%20progression%20of%20emphysema%20in%20individuals%20with%20severe%20AATD%20and%20normal%20forced%20expiratory%20volume%20in%201%20second%20%28FEV1%29.%22%2C%22date%22%3A%222017-07-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.15326%5C%2Fjcopdf.4.3.2016.0180%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Feuropepmc.org%5C%2Farticles%5C%2FPMC5556912%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222372-952X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%2C%22H7G8WGNF%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22QH2IMYNN%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Choi%20et%20al.%22%2C%22parsedDate%22%3A%222017-11-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BChoi%2C%20S.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fbmjopenrespres.bmj.com%5C%2Fcontent%5C%2F4%5C%2F1%5C%2Fe000252%26%23039%3B%26gt%3BDifferentiation%20of%20quantitative%20CT%20imaging%20phenotypes%20in%20asthma%20versus%20COPD%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BBMJ%20Open%20Respiratory%20Research%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B4%26lt%3B%5C%2Fb%26gt%3B%2C%20e000252%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Differentiation%20of%20quantitative%20CT%20imaging%20phenotypes%20in%20asthma%20versus%20COPD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanghun%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Babak%22%2C%22lastName%22%3A%22Haghighi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiwoong%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%20P.%22%2C%22lastName%22%3A%22Comellas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D.%22%2C%22lastName%22%3A%22Newell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sally%20E.%22%2C%22lastName%22%3A%22Wenzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mario%22%2C%22lastName%22%3A%22Castro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%20B.%22%2C%22lastName%22%3A%22Fain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nizar%20N.%22%2C%22lastName%22%3A%22Jarjour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20L.%22%2C%22lastName%22%3A%22Schiebler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K.%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%20R.%22%2C%22lastName%22%3A%22Bleecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20B.%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Couper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Hansel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20E.%22%2C%22lastName%22%3A%22Kanner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ella%20A.%22%2C%22lastName%22%3A%22Kazerooni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%20C.%22%2C%22lastName%22%3A%22Kleerup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wanda%20K.%22%2C%22lastName%22%3A%22O%5Cu2019Neal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prescott%20G.%22%2C%22lastName%22%3A%22Woodruff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ching-Long%22%2C%22lastName%22%3A%22Lin%22%7D%5D%2C%22abstractNote%22%3A%22Density-based%20QCT%20metrics%20measured%20at%20upper%20and%20middle%20lobes%20were%20found%20to%20be%20discriminant%20variables%20between%20patients%20with%20asthma%20and%20COPD.%22%2C%22date%22%3A%222017%5C%2F11%5C%2F01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjresp-2017-000252%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmjopenrespres.bmj.com%5C%2Fcontent%5C%2F4%5C%2F1%5C%2Fe000252%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222052-4439%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%227DGCUGBH%22%2C%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fbmj.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%224L3DXGIH%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cosentino%20et%20al.%22%2C%22parsedDate%22%3A%222016-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BCosentino%2C%20J.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Analysis%20of%20Asthma-Chronic%20Obstructive%20Pulmonary%20Disease%20Overlap%20Syndrome%20Defined%20on%20the%20Basis%20of%20Bronchodilator%20Response%20and%20Degree%20of%20Emphysema.%20%26lt%3Bi%26gt%3BAnn%20Am%20Thorac%20Soc%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B13%26lt%3B%5C%2Fb%26gt%3B%2C%201483%26%23x2013%3B1489%20%282016%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Analysis%20of%20Asthma-Chronic%20Obstructive%20Pulmonary%20Disease%20Overlap%20Syndrome%20Defined%20on%20the%20Basis%20of%20Bronchodilator%20Response%20and%20Degree%20of%20Emphysema%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Cosentino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huaqing%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megan%22%2C%22lastName%22%3A%22Hardin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Craig%20P.%22%2C%22lastName%22%3A%22Hersh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Crapo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerard%20J.%22%2C%22lastName%22%3A%22Criner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22COPDGene%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22The%20aim%20of%20this%20study%20was%20to%20use%20spirometry%20and%20computed%20tomography%20%28CT%29%20to%20help%20better%20define%20ACOS%20as%20well%20as%20to%20classify%20subjects%20with%20ACOS%20based%20on%20Global%20Initiative%20for%20Chronic%20Obstructive%20Lung%20Disease%20%28GOLD%29%20letter%20grade.%22%2C%22date%22%3A%222016-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1513%5C%2FAnnalsATS.201511-761OC%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222325-6621%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%227DGCUGBH%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fats.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22HHZGHGI6%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dilger%20et%20al.%22%2C%22parsedDate%22%3A%222015-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BDilger%2C%20S.%20K.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.spiedigitallibrary.org%5C%2Fjournals%5C%2Fjournal-of-medical-imaging%5C%2Fvolume-2%5C%2Fissue-4%5C%2F041004%5C%2FImproved-pulmonary-nodule-classification-utilizing-quantitative-lung-parenchyma-features%5C%2F10.1117%5C%2F1.JMI.2.4.041004.full%26%23039%3B%26gt%3BImproved%20pulmonary%20nodule%20classification%20utilizing%20quantitative%20lung%20parenchyma%20features%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BJMI%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2%26lt%3B%5C%2Fb%26gt%3B%2C%20041004%20%282015%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Improved%20pulmonary%20nodule%20classification%20utilizing%20quantitative%20lung%20parenchyma%20features%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samantha%20K.%22%2C%22lastName%22%3A%22Dilger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Uthoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Judisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%22%2C%22lastName%22%3A%22Hammond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20L.%22%2C%22lastName%22%3A%22Mott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20J.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D.%20Newell%22%2C%22lastName%22%3A%22Jr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%20C.%22%2C%22lastName%22%3A%22Sieren%22%7D%5D%2C%22abstractNote%22%3A%22These%20results%20show%20a%20trend%20toward%20increased%20performance%20when%20the%20parenchyma%20is%20included%2C%20coupled%20with%20the%20large%20number%20of%20significant%20parenchymal%20features%20that%20support%20our%20hypothesis%3A%20the%20pulmonary%20parenchyma%20is%20influenced%20differentially%20by%20malignant%20versus%20benign%20nodules%2C%20assisting%20CAD-based%20nodule%20characterizations.%22%2C%22date%22%3A%222015%5C%2F09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1117%5C%2F1.JMI.2.4.041004%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.spiedigitallibrary.org%5C%2Fjournals%5C%2Fjournal-of-medical-imaging%5C%2Fvolume-2%5C%2Fissue-4%5C%2F041004%5C%2FImproved-pulmonary-nodule-classification-utilizing-quantitative-lung-parenchyma-features%5C%2F10.1117%5C%2F1.JMI.2.4.041004.full%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222329-4302%2C%202329-4310%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CZ86BF5L%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fjmi.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22JA4XVXDP%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tran%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BTran%2C%20C.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0954611122002475%26%23039%3B%26gt%3BLuminal%20mucus%20plugs%20are%20spatially%20associated%20with%20airway%20wall%20thickening%20in%20severe%20COPD%20and%20asthma%3A%20A%20single-centered%2C%20retrospective%2C%20observational%20study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BRespiratory%20Medicine%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B202%26lt%3B%5C%2Fb%26gt%3B%2C%20106982%20%282022%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Luminal%20mucus%20plugs%20are%20spatially%20associated%20with%20airway%20wall%20thickening%20in%20severe%20COPD%20and%20asthma%3A%20A%20single-centered%2C%20retrospective%2C%20observational%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cecilia%22%2C%22lastName%22%3A%22Tran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaurav%20Veer%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ehsan%22%2C%22lastName%22%3A%22Haider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Colm%22%2C%22lastName%22%3A%22Boylan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Venegas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaista%22%2C%22lastName%22%3A%22Riaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suad%22%2C%22lastName%22%3A%22Al%20Duwaiki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moustafa%22%2C%22lastName%22%3A%22Yehia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Terence%22%2C%22lastName%22%3A%22Ho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Parameswaran%22%2C%22lastName%22%3A%22Nair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Svenningsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Kirby%22%7D%5D%2C%22abstractNote%22%3A%22There%20was%20increased%20airway%20wall%20thickness%20and%20reduced%20airway%20counts%20on%20CT%20in%20segments%20where%20there%20was%20a%20distal%20mucus%20plug%20compared%20to%20segments%20without%20mucus%20plugs%20in%20asthma%20and%20COPD%22%2C%22date%22%3A%2210%5C%2F2022%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.rmed.2022.106982%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0954611122002475%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2209546111%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%227DGCUGBH%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Frespiratory-medicine.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22LLSK4BS4%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Smith%20et%20al.%22%2C%22parsedDate%22%3A%222018-01-30%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BSmith%2C%20B.%20M.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.pnas.org%5C%2Fdoi%5C%2Ffull%5C%2F10.1073%5C%2Fpnas.1715564115%26%23039%3B%26gt%3BHuman%20airway%20branch%20variation%20and%20chronic%20obstructive%20pulmonary%20disease%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BProceedings%20of%20the%20National%20Academy%20of%20Sciences%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B115%26lt%3B%5C%2Fb%26gt%3B%2C%20E974%5Cu2013E981%20%282018%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Human%20airway%20branch%20variation%20and%20chronic%20obstructive%20pulmonary%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20M.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hussein%22%2C%22lastName%22%3A%22Traboulsi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20H.%20M.%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ani%22%2C%22lastName%22%3A%22Manichaikul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%20R.%22%2C%22lastName%22%3A%22Bleecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wellington%20V.%22%2C%22lastName%22%3A%22Cardoso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Couper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20M.%22%2C%22lastName%22%3A%22Dashnaw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jia%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K.%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%20N.%22%2C%22lastName%22%3A%22Hansel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emlyn%20W.%22%2C%22lastName%22%3A%22Hughes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20R.%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20E.%22%2C%22lastName%22%3A%22Kanner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joel%20D.%22%2C%22lastName%22%3A%22Kaufman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Kleerup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ching-Long%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiang%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%20M.%22%2C%22lastName%22%3A%22Lo%20Cascio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%20N.%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20R.%22%2C%22lastName%22%3A%22Prince%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22Rennard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20S.%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leora%22%2C%22lastName%22%3A%22Simon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanping%22%2C%22lastName%22%3A%22Sun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%20E.%22%2C%22lastName%22%3A%22Watson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prescott%20G.%22%2C%22lastName%22%3A%22Woodruff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%20J.%22%2C%22lastName%22%3A%22Baglole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22for%20the%20MESA%20Lung%20and%20SPIROMICS%20investigators%22%7D%5D%2C%22abstractNote%22%3A%22We%20conclude%20that%20central%20airway%20branch%20variation%2C%20readily%20detected%20by%20computed%20tomography%2C%20is%20a%20biomarker%20of%20widely%20altered%20lung%20structure%20with%20a%20genetic%20basis%20and%20represents%20a%20COPD%20susceptibility%20factor.%22%2C%22date%22%3A%222018-01-30%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1073%5C%2Fpnas.1715564115%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.pnas.org%5C%2Fdoi%5C%2Ffull%5C%2F10.1073%5C%2Fpnas.1715564115%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fpnas.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%224CH9LMXJ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Washko%20et%20al.%22%2C%22parsedDate%22%3A%222017-11-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BWashko%2C%20G.%20R.%2C%20Coxson%2C%20H.%20O.%2C%20O%26%23039%3BDonnell%2C%20D.%20E.%20%26amp%3B%20Aaron%2C%20S.%20D.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.thelancet.com%5C%2Fjournals%5C%2Flanres%5C%2Farticle%5C%2FPIIS2213-2600%2817%2930345-4%5C%2Freferences%26%23039%3B%26gt%3BCT%20imaging%20of%20chronic%20obstructive%20pulmonary%20disease%3A%20insights%2C%20disappointments%2C%20and%20promise%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BThe%20Lancet%20Respiratory%20Medicine%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B5%26lt%3B%5C%2Fb%26gt%3B%2C%20903%5Cu2013908%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22CT%20imaging%20of%20chronic%20obstructive%20pulmonary%20disease%3A%20insights%2C%20disappointments%2C%20and%20promise%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%20R.%22%2C%22lastName%22%3A%22Washko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harvey%20O.%22%2C%22lastName%22%3A%22Coxson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%20E.%22%2C%22lastName%22%3A%22O%27Donnell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shawn%20D.%22%2C%22lastName%22%3A%22Aaron%22%7D%5D%2C%22abstractNote%22%3A%22CT%20imaging%20is%20a%20readily%20quantifiable%20tool%20that%20can%20provide%20in-vivo%20assessments%20of%20lung%20structure%20in%20conditions%20such%20as%20chronic%20obstructive%20pulmonary%20disease%20%28COPD%29.%22%2C%22date%22%3A%222017-11-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2213-2600%2817%2930345-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.thelancet.com%5C%2Fjournals%5C%2Flanres%5C%2Farticle%5C%2FPIIS2213-2600%2817%2930345-4%5C%2Freferences%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222213-2600%2C%202213-2619%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Flancet-1.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%226YGL233I%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Belchi%20et%20al.%22%2C%22parsedDate%22%3A%222018-03-28%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBelchi%2C%20F.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-018-23424-0%26%23039%3B%26gt%3BLung%20Topology%20Characteristics%20in%20patients%20with%20Chronic%20Obstructive%20Pulmonary%20Disease%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BSci%20Rep%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B8%26lt%3B%5C%2Fb%26gt%3B%2C%205341%20%282018%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lung%20Topology%20Characteristics%20in%20patients%20with%20Chronic%20Obstructive%20Pulmonary%20Disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francisco%22%2C%22lastName%22%3A%22Belchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariam%22%2C%22lastName%22%3A%22Pirashvili%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joy%22%2C%22lastName%22%3A%22Conway%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Bennett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ratko%22%2C%22lastName%22%3A%22Djukanovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacek%22%2C%22lastName%22%3A%22Brodzki%22%7D%5D%2C%22abstractNote%22%3A%22The%20results%20of%20this%20study%20are%20a%20proof%20of%20concept%20that%20topological%20methods%20can%20enhance%20the%20standard%20methodology%20to%20create%20a%20finer%20classification%20of%20COPD%20and%20increase%20the%20possibilities%20of%20more%20personalized%20treatment.%22%2C%22date%22%3A%222018-03-28%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-018-23424-0%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-018-23424-0%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222045-2322%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22FNJDLJIA%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bhatt%20et%20al.%22%2C%22parsedDate%22%3A%222014-12-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBhatt%2C%20S.%20P.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fthorax.bmj.com%5C%2Fcontent%5C%2F69%5C%2F12%5C%2F1147%26%23039%3B%26gt%3BComparison%20of%20spirometric%20thresholds%20in%20diagnosing%20smoking-related%20airflow%20obstruction%3A%20authors%26%23039%3B%20response%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BThorax%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B69%26lt%3B%5C%2Fb%26gt%3B%2C%201147%5Cu20131148%20%282014%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20spirometric%20thresholds%20in%20diagnosing%20smoking-related%20airflow%20obstruction%3A%20authors%27%20response%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Surya%20P.%22%2C%22lastName%22%3A%22Bhatt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%20R.%22%2C%22lastName%22%3A%22Washko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20T.%22%2C%22lastName%22%3A%22Dransfield%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%20C.%22%2C%22lastName%22%3A%22Sieren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D.%22%2C%22lastName%22%3A%22Newell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%5D%2C%22abstractNote%22%3A%22We%20hope%20that%20our%20study%2C%20which%20provides%20a%20link%20between%20indirect%20metrics%20of%20lung%20function%20to%20a%20more%20direct%20metric%20of%20parenchymal%20pathology%2C%20provides%20a%20basis%20for%20added%20insights%20into%20what%20clearly%20is%20a%20continuing%20controversy.%22%2C%22date%22%3A%222014%5C%2F12%5C%2F01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fthoraxjnl-2014-206123%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fthorax.bmj.com%5C%2Fcontent%5C%2F69%5C%2F12%5C%2F1147%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220040-6376%2C%201468-3296%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fthorax.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%222J3XTEXT%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ostridge%20et%20al.%22%2C%22parsedDate%22%3A%222019-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BOstridge%2C%20K.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.atsjournals.org%5C%2Fdoi%5C%2F10.1513%5C%2FAnnalsATS.201810-669OC%26%23039%3B%26gt%3BUsing%20Novel%20Computed%20Tomography%20Analysis%20to%20Describe%20the%20Contribution%20and%20Distribution%20of%20Emphysema%20and%20Small%20Airways%20Disease%20in%20Chronic%20Obstructive%20Pulmonary%20Disease%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BAnnals%20ATS%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B16%26lt%3B%5C%2Fb%26gt%3B%2C%20990%5Cu2013997%20%282019%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Using%20Novel%20Computed%20Tomography%20Analysis%20to%20Describe%20the%20Contribution%20and%20Distribution%20of%20Emphysema%20and%20Small%20Airways%20Disease%20in%20Chronic%20Obstructive%20Pulmonary%20Disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kristoffer%22%2C%22lastName%22%3A%22Ostridge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerry%22%2C%22lastName%22%3A%22Gove%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karlien%20H.%20W.%22%2C%22lastName%22%3A%22Paas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannah%22%2C%22lastName%22%3A%22Burke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22Harden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Kirby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sam%22%2C%22lastName%22%3A%22Peterson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jered%22%2C%22lastName%22%3A%22Sieren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22McCrae%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Outi%22%2C%22lastName%22%3A%22Vaarala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl%20J.%22%2C%22lastName%22%3A%22Staples%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%20M.%20A.%22%2C%22lastName%22%3A%22Wilkinson%22%7D%5D%2C%22abstractNote%22%3A%22These%20results%20provide%20further%20validation%20for%20the%20use%20of%20DPM%5C%2FPRM%20analysis%20in%20COPD%20by%20demonstrating%20significant%20relationships%20with%20specific%20physiological%20measures%20of%20SAD.%22%2C%22date%22%3A%222019-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1513%5C%2FAnnalsATS.201810-669OC%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.atsjournals.org%5C%2Fdoi%5C%2F10.1513%5C%2FAnnalsATS.201810-669OC%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222329-6933%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fats.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22UGEQX5XQ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gompelmann%20et%20al.%22%2C%22parsedDate%22%3A%222018-02-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BGompelmann%2C%20D.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5798552%5C%2F%26%23039%3B%26gt%3BThe%20minimal%20important%20difference%20for%20target%20lobe%20volume%20reduction%20after%20endoscopic%20valve%20therapy%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BInt%20J%20Chron%20Obstruct%20Pulmon%20Dis%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B13%26lt%3B%5C%2Fb%26gt%3B%2C%20465%5Cu2013472%20%282018%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20minimal%20important%20difference%20for%20target%20lobe%20volume%20reduction%20after%20endoscopic%20valve%20therapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Gompelmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K%22%2C%22lastName%22%3A%22Kontogianni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%22%2C%22lastName%22%3A%22Schuhmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%22%2C%22lastName%22%3A%22Eberhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22CP%22%2C%22lastName%22%3A%22Heussel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22FJ%22%2C%22lastName%22%3A%22Herth%22%7D%5D%2C%22abstractNote%22%3A%22In%20future%2C%20a%20TLVR%20between%2049%25%20and%2054%25%20of%20the%20baseline%20TLV%2C%20should%20be%20used%20when%20interpreting%20the%20clinical%20relevance.%22%2C%22date%22%3A%222018-2-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.2147%5C%2FCOPD.S152029%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5798552%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221176-9106%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fcopd-journal.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22WH5QD7SX%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Yablonskiy%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BYablonskiy%2C%20D.%20A.%20Air%20Trapping%20-%20Insights%20from%20CT%20and%20In%20Vivo%20Lung%20Morphometry%20with%20Hyperpolarized%203He%20MRI.%20%26lt%3Bi%26gt%3BAmerican%20Thoracic%20Society%20International%20Conference%20Meetings%20Abstracts%20American%20Thoracic%20Society%20International%20Conference%20Meetings%20Abstracts%26lt%3B%5C%2Fi%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Air%20Trapping%20-%20Insights%20from%20CT%20and%20In%20Vivo%20Lung%20Morphometry%20with%20Hyperpolarized%203He%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.A.%22%2C%22lastName%22%3A%22Yablonskiy%22%7D%5D%2C%22abstractNote%22%3A%22Higher%20DPM%20airtrapping%20appeared%20to%20always%20be%20associated%20with%20shallow%20acinar%20airways.%22%2C%22date%22%3A%22%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fats.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22LB7J9QQG%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Oliveira%20et%20al.%22%2C%22parsedDate%22%3A%222017-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3Bde%20Oliveira%2C%20H.%20G.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5442791%5C%2F%26%23039%3B%26gt%3BCombined%20Bone%20Marrow%5Cu2010Derived%20Mesenchymal%20Stromal%20Cell%20Therapy%20and%20One%5Cu2010Way%20Endobronchial%20Valve%20Placement%20in%20Patients%20with%20Pulmonary%20Emphysema%3A%20A%20Phase%20I%20Clinical%20Trial%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BStem%20Cells%20Transl%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B6%26lt%3B%5C%2Fb%26gt%3B%2C%20962%5Cu2013969%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Combined%20Bone%20Marrow%5Cu2010Derived%20Mesenchymal%20Stromal%20Cell%20Therapy%20and%20One%5Cu2010Way%20Endobronchial%20Valve%20Placement%20in%20Patients%20with%20Pulmonary%20Emphysema%3A%20A%20Phase%20I%20Clinical%20Trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%20Goulart%22%2C%22lastName%22%3A%22de%20Oliveira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%20Ferreira%22%2C%22lastName%22%3A%22Cruz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariana%20Alves%22%2C%22lastName%22%3A%22Antunes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amarilio%20Vieira%22%2C%22lastName%22%3A%22de%20Macedo%20Neto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guilherme%20Augusto%22%2C%22lastName%22%3A%22Oliveira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabio%20Munhoz%22%2C%22lastName%22%3A%22Svartman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Borgonovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%20Lucia%20Kuniyoshi%22%2C%22lastName%22%3A%22Rebelatto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20J.%22%2C%22lastName%22%3A%22Weiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paulo%20Roberto%20Slud%22%2C%22lastName%22%3A%22Brofman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcelo%20Marcos%22%2C%22lastName%22%3A%22Morales%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%20Roberto%22%2C%22lastName%22%3A%22Lapa%20e%20Silva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%20Rieken%20Macedo%22%2C%22lastName%22%3A%22Rocco%22%7D%5D%2C%22abstractNote%22%3A%22Combined%20use%20of%20EBV%20and%20MSCs%20appears%20to%20be%20safe%20in%20patients%20with%20severe%20COPD%2C%20providing%20a%20basis%20for%20subsequent%20investigations%20using%20MSCs%20as%20concomitant%20therapy.%22%2C%22date%22%3A%222017-3%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fsctm.16-0315%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5442791%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222157-6564%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22HSG4I5IT%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lo%20Cascio%20et%20al.%22%2C%22parsedDate%22%3A%222017-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BLo%20Cascio%2C%20C.%20M.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5472515%5C%2F%26%23039%3B%26gt%3BPercent%20Emphysema%20and%20Daily%20Motor%20Activity%20Levels%20in%20the%20General%20Population%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BChest%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B151%26lt%3B%5C%2Fb%26gt%3B%2C%201039%5Cu20131050%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Percent%20Emphysema%20and%20Daily%20Motor%20Activity%20Levels%20in%20the%20General%20Population%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%20M.%22%2C%22lastName%22%3A%22Lo%20Cascio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirja%22%2C%22lastName%22%3A%22Quante%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%20G.%22%2C%22lastName%22%3A%22Bertoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carrie%20P.%22%2C%22lastName%22%3A%22Aaron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20E.%22%2C%22lastName%22%3A%22Schwartz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20V.%22%2C%22lastName%22%3A%22Avdalovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%20S.%22%2C%22lastName%22%3A%22Fan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%20S.%22%2C%22lastName%22%3A%22Lovasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20M.%22%2C%22lastName%22%3A%22Kawut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20H.M.%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Redline%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22We%20hypothesized%20that%20greater%20percentage%20of%20emphysema-like%20lung%20on%20CT%20scan%20is%20associated%20with%20reduced%20physical%20activity%20assessed%20by%20actigraphy%20and%20self-report.%22%2C%22date%22%3A%222017-5%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.chest.2016.11.033%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5472515%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220012-3692%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fchest.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22NG2K63XB%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Oelsner%20et%20al.%22%2C%22parsedDate%22%3A%222014-12-16%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BOelsner%2C%20E.%20C.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Association%20between%20emphysema-like%20lung%20on%20cardiac%20computed%20tomography%20and%20mortality%20in%20persons%20without%20airflow%20obstruction%3A%20a%20cohort%20study.%20%26lt%3Bi%26gt%3BAnn%20Intern%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B161%26lt%3B%5C%2Fb%26gt%3B%2C%20863%26%23x2013%3B873%20%282014%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20emphysema-like%20lung%20on%20cardiac%20computed%20tomography%20and%20mortality%20in%20persons%20without%20airflow%20obstruction%3A%20a%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20C.%22%2C%22lastName%22%3A%22Oelsner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aaron%20R.%22%2C%22lastName%22%3A%22Folsom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Jeffrey%22%2C%22lastName%22%3A%22Carr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20L.%22%2C%22lastName%22%3A%22Enright%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20M.%22%2C%22lastName%22%3A%22Kawut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Kronmal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Lederer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joao%20A.%20C.%22%2C%22lastName%22%3A%22Lima%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%20S.%22%2C%22lastName%22%3A%22Lovasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%22%2C%22lastName%22%3A%22Shea%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22To%20determine%20whether%20greater%20emphysema-like%20lung%20on%20CT%20is%20associated%20with%20all-cause%20mortality%20among%20persons%20in%20the%20general%20population%20without%20airflow%20obstruction%20or%20COPD.%22%2C%22date%22%3A%222014-12-16%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.7326%5C%2FM13-2570%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221539-3704%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22SQ5XHKGS%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Smith%20et%20al.%22%2C%22parsedDate%22%3A%222014-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BSmith%2C%20B.%20M.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Not%20all%20measures%20of%20hyperinflation%20are%20created%20equal%3A%20lung%20structure%20and%20clinical%20correlates%20of%20gas%20trapping%20and%20hyperexpansion%20in%20COPD%3A%20the%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20%28MESA%29%20COPD%20Study.%20%26lt%3Bi%26gt%3BChest%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B145%26lt%3B%5C%2Fb%26gt%3B%2C%201305%26%23x2013%3B1315%20%282014%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Not%20all%20measures%20of%20hyperinflation%20are%20created%20equal%3A%20lung%20structure%20and%20clinical%20correlates%20of%20gas%20trapping%20and%20hyperexpansion%20in%20COPD%3A%20the%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20%28MESA%29%20COPD%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20M.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20C.%22%2C%22lastName%22%3A%22Basner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20M.%22%2C%22lastName%22%3A%22Kawut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ravi%22%2C%22lastName%22%3A%22Kalhan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22We%20hypothesized%20that%20increased%20residual%20volume%20%28RV%29%20and%20RV%5C%2Ftotal%20lung%20capacity%20%28TLC%29%20would%20be%20associated%20with%20reduced%20airway%20lumen%20dimensions%2C%20whereas%20increased%20functional%20residual%20capacity%20%28FRC%29%2C%20TLC%2C%20and%20reduced%20inspiratory%20capacity%20%28IC%29%5C%2FTLC%20would%20be%20associated%20with%20emphysema%20on%20CT%20scan.%20We%20examined%20whether%20clinical%20characteristics%20differed%20accordingly.%22%2C%22date%22%3A%222014-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1378%5C%2Fchest.13-1884%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221931-3543%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fchest.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22IALX8HL9%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Martinez%20et%20al.%22%2C%22parsedDate%22%3A%222017-02-15%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BMartinez%2C%20C.%20H.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Age%20and%20Small%20Airway%20Imaging%20Abnormalities%20in%20Subjects%20with%20and%20without%20Airflow%20Obstruction%20in%20SPIROMICS.%20%26lt%3Bi%26gt%3BAm%20J%20Respir%20Crit%20Care%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B195%26lt%3B%5C%2Fb%26gt%3B%2C%20464%26%23x2013%3B472%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Age%20and%20Small%20Airway%20Imaging%20Abnormalities%20in%20Subjects%20with%20and%20without%20Airflow%20Obstruction%20in%20SPIROMICS%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlos%20H.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%20A.%22%2C%22lastName%22%3A%22Diaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Meldrum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%20L.%22%2C%22lastName%22%3A%22Curtis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20B.%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cheryl%22%2C%22lastName%22%3A%22Pirozzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20E.%22%2C%22lastName%22%3A%22Kanner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Paine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prescott%20G.%22%2C%22lastName%22%3A%22Woodruff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%20R.%22%2C%22lastName%22%3A%22Bleecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%20N.%22%2C%22lastName%22%3A%22Hansel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathaniel%22%2C%22lastName%22%3A%22Marchetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerard%20J.%22%2C%22lastName%22%3A%22Criner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ella%20A.%22%2C%22lastName%22%3A%22Kazerooni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20D.%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Craig%20J.%22%2C%22lastName%22%3A%22Galban%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%20T.%22%2C%22lastName%22%3A%22Cigolle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K.%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22SPIROMICS%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22We%20used%20parametric%20response%20mapping%20analysis%20of%20paired%20inspiratory%5C%2Fexpiratory%20CTs%20to%20identify%20functional%20small%20airway%20abnormality%20%28PRMFSA%29%20and%20emphysema%20%28PRMEMPH%29%20in%20the%20SPIROMICS%20%28Subpopulations%20and%20Intermediate%20Outcome%20Measures%20in%20COPD%20Study%29%20cohort.%22%2C%22date%22%3A%222017-02-15%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1164%5C%2Frccm.201604-0871OC%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221535-4970%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2F4L_RACCM.jpeg%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%224FNZT6W7%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Newell%20et%20al.%22%2C%22parsedDate%22%3A%222013-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BNewell%2C%20J.%20D.%2C%20Sieren%2C%20J.%20%26amp%3B%20Hoffman%2C%20E.%20A.%20Development%20of%20quantitative%20computed%20tomography%20lung%20protocols.%20%26lt%3Bi%26gt%3BJ%20Thorac%20Imaging%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B28%26lt%3B%5C%2Fb%26gt%3B%2C%20266%26%23x2013%3B271%20%282013%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20of%20quantitative%20computed%20tomography%20lung%20protocols%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D.%22%2C%22lastName%22%3A%22Newell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jered%22%2C%22lastName%22%3A%22Sieren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%5D%2C%22abstractNote%22%3A%22In%20this%20review%2C%20we%20discuss%20the%20following%20important%20topics%3A%20QCT-derived%20metrics%20of%20lung%20disease%3B%20QCT%20scanning%20protocols%3B%20quality%20control%3B%20and%20QCT%20image%20processing%20software.%20We%20will%20briefly%20discuss%20several%20QCT-derived%20metrics%20of%20lung%20disease%20that%20have%20been%20developed%20for%20the%20assessment%20of%20emphysema%2C%20small%20airway%20disease%2C%20and%20large%20airway%20disease.%22%2C%22date%22%3A%222013-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FRTI.0b013e31829f6796%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221536-0237%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%2C%22GQUIDZTK%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F09%5C%2Fdownload-4.jpg%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22A5WUCXXE%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22McAllister%20et%20al.%22%2C%22parsedDate%22%3A%222011-04%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BMcAllister%2C%20D.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC3629728%5C%2F%26%23039%3B%26gt%3BPulmonary%20Function%20is%20Associated%20with%20Distal%20Aortic%20Calcium%2C%20not%20Proximal%20Aortic%20Distensibility.%20MESA%20Lung%20Study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BCOPD%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B8%26lt%3B%5C%2Fb%26gt%3B%2C%2071%5Cu201378%20%282011%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pulmonary%20Function%20is%20Associated%20with%20Distal%20Aortic%20Calcium%2C%20not%20Proximal%20Aortic%20Distensibility.%20MESA%20Lung%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22McAllister%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22MacNee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Duprez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%22%2C%22lastName%22%3A%22Vogel-Claussen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20H.%22%2C%22lastName%22%3A%22Criqui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Budoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A%22%2C%22lastName%22%3A%22Bluemke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22We%20examined%20if%20FEV1%20and%20CT%20percent%20emphysema%20were%20associated%20with%20calcification%20of%20the%20abdominal%20aorta%20or%20reduced%20distensibility%20of%20the%20proximal%20thoracic%20aorta.%22%2C%22date%22%3A%222011-4%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3109%5C%2F15412555.2011.558543%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC3629728%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221541-2555%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22857V75FZ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Han%20et%20al.%22%2C%22parsedDate%22%3A%222010-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BHan%2C%20M.%20K.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Prevalence%20and%20clinical%20correlates%20of%20bronchoreversibility%20in%20severe%20emphysema.%20%26lt%3Bi%26gt%3BEur%20Respir%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B35%26lt%3B%5C%2Fb%26gt%3B%2C%201048%26%23x2013%3B1056%20%282010%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prevalence%20and%20clinical%20correlates%20of%20bronchoreversibility%20in%20severe%20emphysema%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20K.%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Wise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Mumford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Sciurba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20J.%22%2C%22lastName%22%3A%22Criner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20L.%22%2C%22lastName%22%3A%22Curtis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Murray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Sternberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Weinman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Kazerooni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20P.%22%2C%22lastName%22%3A%22Fishman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Make%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Z.%22%2C%22lastName%22%3A%22Mosenifar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%20J.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22NETT%20Research%20Group%22%7D%5D%2C%22abstractNote%22%3A%22We%20hypothesised%20that%20an%20emphysematous%20phenotype%20of%20COPD%20would%20be%20associated%20with%20decreased%20bronchoreversibility.%22%2C%22date%22%3A%222010-05%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1183%5C%2F09031936.00052509%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221399-3003%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2FERS-journal.jpg%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22JWXEG8WN%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Martinez%20et%20al.%22%2C%22parsedDate%22%3A%222007-01-08%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BMartinez%2C%20F.%20J.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fjhu.pure.elsevier.com%5C%2Fen%5C%2Fpublications%5C%2Fsex-differences-in-severe-pulmonary-emphysema-4%26%23039%3B%26gt%3BSex%20differences%20in%20severe%20pulmonary%20emphysema%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BAM.REV.RESPIR.DIS.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B176%26lt%3B%5C%2Fb%26gt%3B%2C%20243%5Cu2013252%20%282007%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sex%20differences%20in%20severe%20pulmonary%20emphysema%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%20L.%22%2C%22lastName%22%3A%22Curtis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Sciurba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanette%22%2C%22lastName%22%3A%22Mumford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22Giardino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gail%22%2C%22lastName%22%3A%22Weinmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ella%22%2C%22lastName%22%3A%22Kazerooni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Murray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerard%20J.%22%2C%22lastName%22%3A%22Criner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donald%20D.%22%2C%22lastName%22%3A%22Sin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Hogg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20L.%22%2C%22lastName%22%3A%22Ries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meilan%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alfred%20P.%22%2C%22lastName%22%3A%22Fishman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barry%22%2C%22lastName%22%3A%22Make%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zab%22%2C%22lastName%22%3A%22Mohsenifar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Wise%22%7D%5D%2C%22abstractNote%22%3A%22To%20compare%20male%20and%20female%20emphysema%20patients%20with%20severe%20disease.%22%2C%22date%22%3A%222007%5C%2F01%5C%2F08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1164%5C%2Frccm.200606-828OC%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjhu.pure.elsevier.com%5C%2Fen%5C%2Fpublications%5C%2Fsex-differences-in-severe-pulmonary-emphysema-4%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221073-449X%22%2C%22language%22%3A%22English%20%28US%29%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2F4L_RACCM.jpeg%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%227MYFDGFL%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Burkart%20et%20al.%22%2C%22parsedDate%22%3A%222014-04%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBurkart%2C%20K.%20M.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4041087%5C%2F%26%23039%3B%26gt%3BAPOM%20and%20High-Density%20Lipoprotein%20are%20associated%20with%20Lung%20Function%20and%20Percent%20Emphysema%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BEur%20Respir%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B43%26lt%3B%5C%2Fb%26gt%3B%2C%201003%5Cu20131017%20%282014%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22APOM%20and%20High-Density%20Lipoprotein%20are%20associated%20with%20Lung%20Function%20and%20Percent%20Emphysema%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kristin%20M%22%2C%22lastName%22%3A%22Burkart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ani%22%2C%22lastName%22%3A%22Manichaikul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jemma%20B%22%2C%22lastName%22%3A%22Wilk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Firas%20S%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20L%22%2C%22lastName%22%3A%22Burke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Enright%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%20N%22%2C%22lastName%22%3A%22Hansel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Demondes%22%2C%22lastName%22%3A%22Haynes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%20R%22%2C%22lastName%22%3A%22Heckbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joel%20D%22%2C%22lastName%22%3A%22Kaufman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%22%2C%22lastName%22%3A%22Kurai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Loehr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20J%22%2C%22lastName%22%3A%22London%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yang%22%2C%22lastName%22%3A%22Meng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%20T%22%2C%22lastName%22%3A%22O%5Cu2019Connor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Oelsner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcy%22%2C%22lastName%22%3A%22Petrini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tess%20D%22%2C%22lastName%22%3A%22Pottinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20A%22%2C%22lastName%22%3A%22Powell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Redline%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%20I%22%2C%22lastName%22%3A%22Rotter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lewis%20J%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mar%5Cu00eda%20Soler%22%2C%22lastName%22%3A%22Artigas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20D%22%2C%22lastName%22%3A%22Tobin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20Y%22%2C%22lastName%22%3A%22Tsai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%22%2C%22lastName%22%3A%22Watson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wendy%22%2C%22lastName%22%3A%22White%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taylor%20R%22%2C%22lastName%22%3A%22Young%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20S%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22We%20assessed%20the%20association%20of%20lung%20function%20with%202%2C100%20genes%20selected%20for%20cardiovascular%20diseases%20among%2020%2C077%20European-Americans%20and%206%2C900%20African-Americans.%20We%20performed%20replication%20of%20significant%20loci%20in%20the%20other%20racial%20group%20and%20an%20independent%20consortium%20of%20Europeans%2C%20tested%20the%20associations%20of%20significant%20loci%20with%20percent%20emphysema%2C%20and%20examined%20gene%20expression%20in%20an%20independent%20sample.%22%2C%22date%22%3A%222014-4%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1183%5C%2F09031936.00147612%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4041087%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220903-1936%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2FERS-journal.jpg%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22DGEGKL46%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Powell%20et%20al.%22%2C%22parsedDate%22%3A%222013-07%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BPowell%2C%20R.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Genetic%20ancestry%20and%20the%20relationship%20of%20cigarette%20smoking%20to%20lung%20function%20and%20per%20cent%20emphysema%20in%20four%20race%5C%2Fethnic%20groups%3A%20a%20cross-sectional%20study.%20%26lt%3Bi%26gt%3BThorax%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B68%26lt%3B%5C%2Fb%26gt%3B%2C%20634%26%23x2013%3B642%20%282013%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Genetic%20ancestry%20and%20the%20relationship%20of%20cigarette%20smoking%20to%20lung%20function%20and%20per%20cent%20emphysema%20in%20four%20race%5C%2Fethnic%20groups%3A%20a%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rhea%22%2C%22lastName%22%3A%22Powell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Duncan%22%2C%22lastName%22%3A%22Davidson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jasmin%22%2C%22lastName%22%3A%22Divers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ani%22%2C%22lastName%22%3A%22Manichaikul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Jeffrey%22%2C%22lastName%22%3A%22Carr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Detrano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20A.%22%2C%22lastName%22%3A%22Kronmal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiang%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naresh%20M.%22%2C%22lastName%22%3A%22Punjabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eyal%22%2C%22lastName%22%3A%22Shahar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%20E.%22%2C%22lastName%22%3A%22Watson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%20I.%22%2C%22lastName%22%3A%22Rotter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kent%20D.%22%2C%22lastName%22%3A%22Taylor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20S.%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22To%20test%20the%20hypothesis%20that%20relationships%20of%20smoking%20to%20lung%20function%20and%20per%20cent%20emphysema%20differ%20by%20genetic%20ancestry%20and%20self-reported%20race%5C%2Fethnicity%20among%20Caucasians%2C%20African-Americans%2C%20Hispanics%20and%20Chinese-Americans.%22%2C%22date%22%3A%222013-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fthoraxjnl-2012-202116%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221468-3296%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fthorax.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22HKJ7HAXQ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Barr%20et%20al.%22%2C%22parsedDate%22%3A%222010-01-21%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBarr%2C%20R.%20G.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC2887729%5C%2F%26%23039%3B%26gt%3BPercent%20Emphysema%2C%20Airflow%20Obstruction%2C%20and%20Impaired%20Left%20Ventricular%20Filling%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BN%20Engl%20J%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B362%26lt%3B%5C%2Fb%26gt%3B%2C%20217%5Cu2013227%20%282010%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Percent%20Emphysema%2C%20Airflow%20Obstruction%2C%20and%20Impaired%20Left%20Ventricular%20Filling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A.%22%2C%22lastName%22%3A%22Bluemke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Firas%20S.%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Jeffery%22%2C%22lastName%22%3A%22Carr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20L.%22%2C%22lastName%22%3A%22Enright%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20M.%22%2C%22lastName%22%3A%22Kawut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20A.%22%2C%22lastName%22%3A%22Kronmal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jo%5Cu00e3o%20A.C.%22%2C%22lastName%22%3A%22Lima%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eyal%22%2C%22lastName%22%3A%22Shahar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lewis%20J.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%20E.%22%2C%22lastName%22%3A%22Watson%22%7D%5D%2C%22abstractNote%22%3A%22We%20hypothesized%20that%20emphysema%2C%20as%20detected%20on%20computed%20tomography%20%28CT%29%2C%20and%20airflow%20obstruction%20are%20inversely%20related%20to%20left%20ventricular%20end-diastolic%20volume%2C%20stroke%20volume%2C%20and%20cardiac%20output%20among%20persons%20without%20very%20severe%20lung%20disease.%22%2C%22date%22%3A%222010-1-21%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1056%5C%2FNEJMoa0808836%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC2887729%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220028-4793%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fnejm.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22CUF68ZS6%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Krachman%20et%20al.%22%2C%22parsedDate%22%3A%222016-07%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BKrachman%2C%20S.%20L.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Effect%20of%20Emphysema%20Severity%20on%20the%20Apnea-Hypopnea%20Index%20in%20Smokers%20with%20Obstructive%20Sleep%20Apnea.%20%26lt%3Bi%26gt%3BAnn%20Am%20Thorac%20Soc%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B13%26lt%3B%5C%2Fb%26gt%3B%2C%201129%26%23x2013%3B1135%20%282016%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20Emphysema%20Severity%20on%20the%20Apnea-Hypopnea%20Index%20in%20Smokers%20with%20Obstructive%20Sleep%20Apnea%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%20L.%22%2C%22lastName%22%3A%22Krachman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachna%22%2C%22lastName%22%3A%22Tiwari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Elena%22%2C%22lastName%22%3A%22Vega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daohai%22%2C%22lastName%22%3A%22Yu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Soler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fredric%22%2C%22lastName%22%3A%22Jaffe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%22%2C%22lastName%22%3A%22Swift%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilbert%20E.%22%2C%22lastName%22%3A%22D%27Alonzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerard%20J.%22%2C%22lastName%22%3A%22Criner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22COPDGene%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22To%20evaluate%20the%20importance%20of%20lung%20inflation%20on%20OSA%20severity%20%28apnea-hypopnea%20index%20%5BAHI%5D%29%20in%20smokers%20with%20suspected%20OSA.%22%2C%22date%22%3A%222016-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1513%5C%2FAnnalsATS.201511-765OC%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222325-6621%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fats.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22GM8H43RG%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Parikh%20et%20al.%22%2C%22parsedDate%22%3A%222017-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BParikh%2C%20M.%20A.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5427735%5C%2F%26%23039%3B%26gt%3BAngiotensin-Converting%20Inhibitors%20and%20Angiotensin%20II%20Receptor%20Blockers%20and%20Longitudinal%20Change%20in%20Percent%20Emphysema%20on%20Computed%20Tomography.%20The%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20Lung%20Study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BAnn%20Am%20Thorac%20Soc%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B14%26lt%3B%5C%2Fb%26gt%3B%2C%20649%5Cu2013658%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Angiotensin-Converting%20Inhibitors%20and%20Angiotensin%20II%20Receptor%20Blockers%20and%20Longitudinal%20Change%20in%20Percent%20Emphysema%20on%20Computed%20Tomography.%20The%20Multi-Ethnic%20Study%20of%20Atherosclerosis%20Lung%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megha%20A.%22%2C%22lastName%22%3A%22Parikh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carrie%20P.%22%2C%22lastName%22%3A%22Aaron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20E.%22%2C%22lastName%22%3A%22Schwartz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaime%22%2C%22lastName%22%3A%22Madrigano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20H.%20M.%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ravi%22%2C%22lastName%22%3A%22Kalhan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%22%2C%22lastName%22%3A%22Lovasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%22%2C%22lastName%22%3A%22Watson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%20Hinckley%22%2C%22lastName%22%3A%22Stukovsky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22To%20determine%20whether%20angiotensin-converting%20enzyme%20%28ACE%29%20inhibitor%20and%20ARB%20dose%20is%20associated%20with%20slowed%20progression%20of%20percent%20emphysema%20by%20CT.%22%2C%22date%22%3A%222017-5%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1513%5C%2FAnnalsATS.201604-317OC%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5427735%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222329-6933%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fats.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22KL9T4QBZ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xu%20et%20al.%22%2C%22parsedDate%22%3A%222006-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BXu%2C%20Y.%2C%20Sonka%2C%20M.%2C%20McLennan%2C%20G.%2C%20Guo%2C%20J.%20%26amp%3B%20Hoffman%2C%20E.%20A.%20MDCT-based%203-D%20texture%20classification%20of%20emphysema%20and%20early%20smoking%20related%20lung%20pathologies.%20%26lt%3Bi%26gt%3BIEEE%20Trans%20Med%20Imaging%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B25%26lt%3B%5C%2Fb%26gt%3B%2C%20464%26%23x2013%3B475%20%282006%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MDCT-based%203-D%20texture%20classification%20of%20emphysema%20and%20early%20smoking%20related%20lung%20pathologies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ye%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milan%22%2C%22lastName%22%3A%22Sonka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22McLennan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junfeng%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%5D%2C%22abstractNote%22%3A%22We%20performed%20MDCT%20on%2034%20humans%20and%20classified%20volumes%20of%20interest%20%28VOIs%29%20in%20the%20MDCT%20images%20into%20five%20categories%3A%20EC%2C%20emphysema%20in%20severe%20chronic%20obstructive%20pulmonary%20disease%20%28COPD%29%3B%20MC%2C%20mild%20emphysema%20in%20mild%20COPD%3B%20NC%2C%20normal%20appearing%20lung%20in%20mild%20COPD%3B%20NN%2C%20normal%20appearing%20lung%20in%20normal%20nonsmokers%3B%20and%20NS%2C%20normal%20appearing%20lung%20in%20normal%20smokers.%22%2C%22date%22%3A%222006-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1109%5C%2FTMI.2006.870889%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220278-0062%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22CUULNCG8%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F10%5C%2Fdownload.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22KMHT68UI%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zach%20et%20al.%22%2C%22parsedDate%22%3A%222012-10%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BZach%2C%20J.%20A.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Quantitative%20computed%20tomography%20of%20the%20lungs%20and%20airways%20in%20healthy%20nonsmoking%20adults.%20%26lt%3Bi%26gt%3BInvest%20Radiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B47%26lt%3B%5C%2Fb%26gt%3B%2C%20596%26%23x2013%3B602%20%282012%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Quantitative%20computed%20tomography%20of%20the%20lungs%20and%20airways%20in%20healthy%20nonsmoking%20adults%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20Alexander%22%2C%22lastName%22%3A%22Zach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20D.%22%2C%22lastName%22%3A%22Newell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joyce%22%2C%22lastName%22%3A%22Schroeder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20R.%22%2C%22lastName%22%3A%22Murphy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Douglas%22%2C%22lastName%22%3A%22Curran-Everett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20M.%22%2C%22lastName%22%3A%22Westgate%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%20K.%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edwin%20K.%22%2C%22lastName%22%3A%22Silverman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20D.%22%2C%22lastName%22%3A%22Crapo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A.%22%2C%22lastName%22%3A%22Lynch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22COPDGene%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22The%20purposes%20of%20this%20study%20were%20to%20evaluate%20the%20reference%20range%20of%20quantitative%20computed%20tomography%20%28QCT%29%20measures%20of%20lung%20attenuation%20and%20airway%20parameter%20measurements%20in%20healthy%20nonsmoking%20adults%20and%20to%20identify%20sources%20of%20variation%20in%20those%20measures%20and%20possible%20means%20to%20adjust%20for%20them.%22%2C%22date%22%3A%222012-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FRLI.0b013e318262292e%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221536-0210%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22YRXIESTN%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22CR3NCMLD%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sieren%20et%20al.%22%2C%22parsedDate%22%3A%222012-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BSieren%2C%20J.%20P.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Reference%20standard%20and%20statistical%20model%20for%20intersite%20and%20temporal%20comparisons%20of%20CT%20attenuation%20in%20a%20multicenter%20quantitative%20lung%20study.%20%26lt%3Bi%26gt%3BMed%20Phys%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B39%26lt%3B%5C%2Fb%26gt%3B%2C%205757%26%23x2013%3B5767%20%282012%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reference%20standard%20and%20statistical%20model%20for%20intersite%20and%20temporal%20comparisons%20of%20CT%20attenuation%20in%20a%20multicenter%20quantitative%20lung%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20P.%22%2C%22lastName%22%3A%22Sieren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20D.%22%2C%22lastName%22%3A%22Newell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%20F.%22%2C%22lastName%22%3A%22Judy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%20A.%22%2C%22lastName%22%3A%22Lynch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20S.%22%2C%22lastName%22%3A%22Chan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%5D%2C%22abstractNote%22%3A%22The%20purpose%20of%20this%20study%20was%20to%20detect%20and%20analyze%20anomalies%20between%20a%20large%20number%20of%20computed%20tomography%20%28CT%29%20scanners%2C%20tracked%20over%20time%2C%20utilized%20to%20collect%20human%20pulmonary%20CT%20data%20for%20a%20national%20multicenter%20study%3A%20chronic%20obstructive%20pulmonary%20disease%20genetic%20epidemiology%20study%20%28COPDGene%29.%22%2C%22date%22%3A%222012-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1118%5C%2F1.4747342%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220094-2405%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22YRXIESTN%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22Q42DT6D4%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Putman%20et%20al.%22%2C%22parsedDate%22%3A%222016-02-16%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BPutman%2C%20R.%20K.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Association%20Between%20Interstitial%20Lung%20Abnormalities%20and%20All-Cause%20Mortality.%20%26lt%3Bi%26gt%3BJAMA%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B315%26lt%3B%5C%2Fb%26gt%3B%2C%20672%26%23x2013%3B681%20%282016%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20Between%20Interstitial%20Lung%20Abnormalities%20and%20All-Cause%20Mortality%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%20K.%22%2C%22lastName%22%3A%22Putman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroto%22%2C%22lastName%22%3A%22Hatabu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tetsuro%22%2C%22lastName%22%3A%22Araki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunnar%22%2C%22lastName%22%3A%22Gudmundsson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mizuki%22%2C%22lastName%22%3A%22Nishino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuka%22%2C%22lastName%22%3A%22Okajima%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9e%22%2C%22lastName%22%3A%22Dupuis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanne%20C.%22%2C%22lastName%22%3A%22Latourelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20H.%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Souheil%22%2C%22lastName%22%3A%22El-Chemaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harvey%20O.%22%2C%22lastName%22%3A%22Coxson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bartolome%20R.%22%2C%22lastName%22%3A%22Celli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isis%20E.%22%2C%22lastName%22%3A%22Fernandez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oscar%20E.%22%2C%22lastName%22%3A%22Zazueta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20C.%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rola%22%2C%22lastName%22%3A%22Harmouche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ra%5Cu00fal%20San%20Jos%5Cu00e9%22%2C%22lastName%22%3A%22Est%5Cu00e9par%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%20A.%22%2C%22lastName%22%3A%22Diaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigurdur%22%2C%22lastName%22%3A%22Sigurdsson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22El%5Cu00edas%20F.%22%2C%22lastName%22%3A%22Gudmundsson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gudny%22%2C%22lastName%22%3A%22Eir%5Cu00edksdott%5Cu00edr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thor%22%2C%22lastName%22%3A%22Aspelund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20J.%22%2C%22lastName%22%3A%22Budoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20L.%22%2C%22lastName%22%3A%22Kinney%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20E.%22%2C%22lastName%22%3A%22Hokanson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michelle%20C.%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20T.%22%2C%22lastName%22%3A%22Murchison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22MacNee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Udo%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20J.%22%2C%22lastName%22%3A%22O%27Donnell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lenore%20J.%22%2C%22lastName%22%3A%22Launer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%20B.%22%2C%22lastName%22%3A%22Harrris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vilmundur%22%2C%22lastName%22%3A%22Gudnason%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edwin%20K.%22%2C%22lastName%22%3A%22Silverman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%20T.%22%2C%22lastName%22%3A%22O%27Connor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%20R.%22%2C%22lastName%22%3A%22Washko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%20O.%22%2C%22lastName%22%3A%22Rosas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%20M.%22%2C%22lastName%22%3A%22Hunninghake%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Evaluation%20of%20COPD%20Longitudinally%20to%20Identify%20Predictive%20Surrogate%20Endpoints%20%28ECLIPSE%29%20Investigators%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22COPDGene%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22To%20investigate%20whether%20interstitial%20lung%20abnormalities%20are%20associated%20with%20increased%20mortality.%22%2C%22date%22%3A%222016-02-16%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1001%5C%2Fjama.2016.0518%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221538-3598%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22MX4T357K%22%2C%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%2C%22image%22%3A%5B%22https%3A%5C%2F%5C%2Fi0.wp.com%5C%2Fvidalung.ai%5C%2Fwp-content%5C%2Fuploads%5C%2F2022%5C%2F06%5C%2Fjama.png%3Fresize%3D150%252C150%26ssl%3D1%22%2C150%2C150%2Ctrue%5D%7D%2C%7B%22key%22%3A%22S79SHDYM%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xu%20et%20al.%22%2C%22parsedDate%22%3A%222005-04-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BXu%2C%20Y.%2C%20Sonka%2C%20M.%2C%20McLennan%2C%20G.%2C%20Guo%2C%20J.%20%26amp%3B%20Hoffman%2C%20E.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fui.adsabs.harvard.edu%5C%2Fabs%5C%2F2005SPIE.5746..474X%26%23039%3B%26gt%3BSensitivity%20and%20specificity%20of%203-D%20texture%20analysis%20of%20lung%20parenchyma%20is%20better%20than%202-D%20for%20discrimination%20of%20lung%20pathology%20in%20stage%200%20COPD%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bb%26gt%3B5746%26lt%3B%5C%2Fb%26gt%3B%2C%20474%5Cu2013485%20%282005%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sensitivity%20and%20specificity%20of%203-D%20texture%20analysis%20of%20lung%20parenchyma%20is%20better%20than%202-D%20for%20discrimination%20of%20lung%20pathology%20in%20stage%200%20COPD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ye%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milan%22%2C%22lastName%22%3A%22Sonka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22McLennan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junfeng%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Hoffman%22%7D%5D%2C%22abstractNote%22%3A%22We%20performed%20MDCT%20on%2034%20human%20volunteers%20in%20five%20categories%3A%20emphysema%20in%20severe%20Chronic%20Obstructive%20Pulmonary%20Disease%20%28COPD%29%20as%20EC%2C%20emphysema%20in%20mild%20COPD%20%28MC%29%2C%20normal%20appearing%20lung%20in%20COPD%20%28NC%29%2C%20non-smokers%20with%20normal%20lung%20function%20%28NN%29%2C%20smokers%20with%20normal%20function%20%28NS%29.%20We%20volumetrically%20excluded%20the%20airway%20and%20vessel%20regions%2C%20calculated%2024%20volumetric%20texture%20features%20for%20each%20Volume%20of%20Interest%20%28VOI%29.%22%2C%22date%22%3A%222005-04-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1117%5C%2F12.595879%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fui.adsabs.harvard.edu%5C%2Fabs%5C%2F2005SPIE.5746..474X%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22GQUIDZTK%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%224MZ3PY23%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hueper%20et%20al.%22%2C%22parsedDate%22%3A%222015-09-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BHueper%2C%20K.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Feuropepmc.org%5C%2Farticles%5C%2FPMC4595687%26%23039%3B%26gt%3BPulmonary%20Microvascular%20Blood%20Flow%20in%20Mild%20Chronic%20Obstructive%20Pulmonary%20Disease%20and%20Emphysema.%20The%20MESA%20COPD%20Study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BAm%20J%20Respir%20Crit%20Care%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B192%26lt%3B%5C%2Fb%26gt%3B%2C%20570%5Cu2013580%20%282015%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pulmonary%20Microvascular%20Blood%20Flow%20in%20Mild%20Chronic%20Obstructive%20Pulmonary%20Disease%20and%20Emphysema.%20The%20MESA%20COPD%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katja%22%2C%22lastName%22%3A%22Hueper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%22%2C%22lastName%22%3A%22Vogel-Claussen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megha%20A%22%2C%22lastName%22%3A%22Parikh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20H%20M%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A%22%2C%22lastName%22%3A%22Bluemke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Carr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiwoong%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20A%22%2C%22lastName%22%3A%22Goldstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoinette%20S%22%2C%22lastName%22%3A%22Gomes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20M%22%2C%22lastName%22%3A%22Kawut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joao%22%2C%22lastName%22%3A%22Lima%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erin%20D%22%2C%22lastName%22%3A%22Michos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wendy%20S%22%2C%22lastName%22%3A%22Post%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ming%20Jack%22%2C%22lastName%22%3A%22Po%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20R%22%2C%22lastName%22%3A%22Prince%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiang%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan%22%2C%22lastName%22%3A%22Rabinowitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Skrok%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%20M%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%22%2C%22lastName%22%3A%22Watson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Youbing%22%2C%22lastName%22%3A%22Yin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alan%20M%22%2C%22lastName%22%3A%22Zambeli-Ljepovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%5D%2C%22abstractNote%22%3A%22To%20investigate%20whether%20PMBF%20is%20reduced%20in%20mild%20as%20well%20as%20more%20severe%20chronic%20obstructive%20pulmonary%20disease%20%28COPD%29%20and%20emphysema.%22%2C%22date%22%3A%222015-09-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1164%5C%2Frccm.201411-2120oc%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Feuropepmc.org%5C%2Farticles%5C%2FPMC4595687%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221535-4970%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22GQUIDZTK%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%225C9NLLSK%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kim%20et%20al.%22%2C%22parsedDate%22%3A%222014-04-27%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BKim%2C%20V.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1465-9921-15-52%26%23039%3B%26gt%3BClinical%20and%20computed%20tomographic%20predictors%20of%20chronic%20bronchitis%20in%20COPD%3A%20a%20cross%20sectional%20analysis%20of%20the%20COPDGene%20study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BRespiratory%20Research%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B15%26lt%3B%5C%2Fb%26gt%3B%2C%2052%20%282014%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20and%20computed%20tomographic%20predictors%20of%20chronic%20bronchitis%20in%20COPD%3A%20a%20cross%20sectional%20analysis%20of%20the%20COPDGene%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%22%2C%22lastName%22%3A%22Davey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%20P.%22%2C%22lastName%22%3A%22Comellas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meilan%20K.%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%22%2C%22lastName%22%3A%22Washko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlos%20H.%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Lynch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jin%20Hwa%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edwin%20K.%22%2C%22lastName%22%3A%22Silverman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20D.%22%2C%22lastName%22%3A%22Crapo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barry%20J.%22%2C%22lastName%22%3A%22Make%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerard%20J.%22%2C%22lastName%22%3A%22Criner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22The%20COPDGene%5Cu00ae%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22We%20sought%20to%20further%20refine%20our%20clinical%20characterization%20of%20chronic%20bronchitics%20in%20a%20larger%20cohort%20and%20analyze%20the%20CT%20correlates%20of%20CB%20in%20COPD%20subjects.%20We%20hypothesized%20that%20COPD%20patients%20with%20CB%20would%20have%20thicker%20airways%20and%20a%20greater%20history%20of%20smoking%2C%20acute%20bronchitis%2C%20allergic%20rhinitis%2C%20and%20occupational%20exposures%20compared%20to%20those%20without%20CB.%22%2C%22date%22%3A%222014-04-27%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2F1465-9921-15-52%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1465-9921-15-52%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221465-993X%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22GQUIDZTK%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%2298D5DMVK%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Iyer%20et%20al.%22%2C%22parsedDate%22%3A%222014%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BIyer%2C%20K.%20S.%2C%20Grout%2C%20R.%20W.%2C%20Zamba%2C%20G.%20K.%20%26amp%3B%20Hoffman%2C%20E.%20A.%20Repeatability%20and%20Sample%20Size%20Assessment%20Associated%20with%20Computed%20Tomography-Based%20Lung%20Density%20Metrics.%20%26lt%3Bi%26gt%3BChronic%20Obstr%20Pulm%20Dis%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B1%26lt%3B%5C%2Fb%26gt%3B%2C%2097%26%23x2013%3B104%20%282014%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Repeatability%20and%20Sample%20Size%20Assessment%20Associated%20with%20Computed%20Tomography-Based%20Lung%20Density%20Metrics%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krishna%20S.%22%2C%22lastName%22%3A%22Iyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Randall%20W.%22%2C%22lastName%22%3A%22Grout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gideon%20K.%22%2C%22lastName%22%3A%22Zamba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%5D%2C%22abstractNote%22%3A%22The%20aim%20of%20this%20study%20was%20to%20evaluate%20the%20repeatability%20of%20single%20center%2C%20CT-based%20density%20metrics%20of%20the%20lung%20in%20a%20normal%20population%20and%20assess%20study%20sample%20sizes%20needed%20to%20detect%20meaningful%20changes%20in%20lung%20density%20metrics%20when%20scan%20parameters%20and%20volumes%20are%20tightly%20controlled.%22%2C%22date%22%3A%222014%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.15326%5C%2Fjcopdf.1.1.2014.0111%23sthash.nxTDeRi7.dpuf%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222372-952X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22GQUIDZTK%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22P655AMLK%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chen-Mayer%20et%20al.%22%2C%22parsedDate%22%3A%222017-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BChen-Mayer%2C%20H.%20H.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC6276120%5C%2F%26%23039%3B%26gt%3BStandardizing%20CT%20lung%20density%20measure%20across%20scanner%20manufacturers%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BMed%20Phys%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B44%26lt%3B%5C%2Fb%26gt%3B%2C%20974%5Cu2013985%20%282017%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Standardizing%20CT%20lung%20density%20measure%20across%20scanner%20manufacturers%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huaiyu%20Heather%22%2C%22lastName%22%3A%22Chen-Mayer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20K.%22%2C%22lastName%22%3A%22Fuld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernice%22%2C%22lastName%22%3A%22Hoppel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20F.%22%2C%22lastName%22%3A%22Judy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jered%20P.%22%2C%22lastName%22%3A%22Sieren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junfeng%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A.%22%2C%22lastName%22%3A%22Lynch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonio%22%2C%22lastName%22%3A%22Possolo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%20B.%22%2C%22lastName%22%3A%22Fain%22%7D%5D%2C%22abstractNote%22%3A%22To%20reduce%20variability%20in%20the%20density%20metrics%20specified%20by%20CT%20attenuation%2C%20the%20Quantitative%20Imaging%20Biomarkers%20Alliance%20%28QIBA%29%20Lung%20Density%20Committee%20has%20organized%20efforts%20to%20conduct%20phantom%20studies%20in%20a%20variety%20of%20scanner%20models%20to%20establish%20a%20baseline%20for%20assessing%20the%20variations%20in%20patient%20studies%20that%20can%20be%20attributed%20to%20scanner%20calibration%20and%20measurement%20uncertainty.%22%2C%22date%22%3A%222017-3%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fmp.12087%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC6276120%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220094-2405%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%22GQUIDZTK%22%5D%2C%22dateModified%22%3A%222022-10-27T20%3A27%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22CQKGMDSI%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Moslemi%20et%20al.%22%2C%22parsedDate%22%3A%222022-06-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BMoslemi%2C%20A.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Quantitative%20CT%20Lung%20Imaging%20and%20Machine%20Learning%20Improves%20Prediction%20of%20Emergency%20Room%20Visits%20and%20Hospitalizations%20in%20COPD.%20%26lt%3Bi%26gt%3BAcad%20Radiol%26lt%3B%5C%2Fi%26gt%3B%20S1076-6332%2822%2900311%26%23x2013%3B7%20%282022%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.acra.2022.05.009%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.acra.2022.05.009%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Quantitative%20CT%20Lung%20Imaging%20and%20Machine%20Learning%20Improves%20Prediction%20of%20Emergency%20Room%20Visits%20and%20Hospitalizations%20in%20COPD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amir%22%2C%22lastName%22%3A%22Moslemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kalysta%22%2C%22lastName%22%3A%22Makimoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wan%20C.%22%2C%22lastName%22%3A%22Tan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Bourbeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20C.%22%2C%22lastName%22%3A%22Hogg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harvey%20O.%22%2C%22lastName%22%3A%22Coxson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Kirby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Canadian%20Cohort%20of%20Obstructive%20Lung%20Disease%22%7D%5D%2C%22abstractNote%22%3A%22The%20combination%20of%20CT%20lung%20imaging%20and%20conventional%20measurements%20leads%20to%20greater%20prediction%20accuracy%20of%20subsequent%20health%20services%20use%20than%20conventional%20measurements%20alone%2C%20and%20may%20provide%20needed%20prognostic%20information%20for%20patients%20suffering%20from%20COPD.%22%2C%22date%22%3A%222022-06-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.acra.2022.05.009%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221878-4046%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-12-22T15%3A52%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22QCRSG27N%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Makimoto%20et%20al.%22%2C%22parsedDate%22%3A%222022-08-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BMakimoto%2C%20K.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Comparison%20of%20Feature%20Selection%20Methods%20and%20Machine%20Learning%20Classifiers%20for%20Predicting%20Chronic%20Obstructive%20Pulmonary%20Disease%20Using%20Texture-Based%20CT%20Lung%20Radiomic%20Features.%20%26lt%3Bi%26gt%3BAcad%20Radiol%26lt%3B%5C%2Fi%26gt%3B%20S1076-6332%2822%2900412%26%23x2013%3B3%20%282022%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.acra.2022.07.016%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.acra.2022.07.016%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20Feature%20Selection%20Methods%20and%20Machine%20Learning%20Classifiers%20for%20Predicting%20Chronic%20Obstructive%20Pulmonary%20Disease%20Using%20Texture-Based%20CT%20Lung%20Radiomic%20Features%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kalysta%22%2C%22lastName%22%3A%22Makimoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%22%2C%22lastName%22%3A%22Au%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amir%22%2C%22lastName%22%3A%22Moslemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20C.%22%2C%22lastName%22%3A%22Hogg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Bourbeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wan%20C.%22%2C%22lastName%22%3A%22Tan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Kirby%22%7D%5D%2C%22abstractNote%22%3A%22In%20a%20population-based%20cohort%2C%20the%20optimal%20combination%20for%20radiomics-based%20prediction%20of%20COPD%20status%20was%20Elastic%20Net%20as%20the%20feature%20selection%20method%20and%20Linear-SVM%20as%20the%20classifier.%22%2C%22date%22%3A%222022-08-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.acra.2022.07.016%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221878-4046%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222022-12-22T15%3A53%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22FP9C25BE%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kizhakke%20Puliyakote%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BKizhakke%20Puliyakote%2C%20A.%20S.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fjournals.physiology.org%5C%2Fdoi%5C%2F10.1152%5C%2Fjapplphysiol.00286.2022%26%23039%3B%26gt%3BImaging-based%20assessment%20of%20lung%20function%20in%20a%20population%20cooking%20indoors%20with%20biomass%20fuel%3A%20a%20pilot%20study%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BJournal%20of%20Applied%20Physiology%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B134%26lt%3B%5C%2Fb%26gt%3B%2C%20710%5Cu2013721%20%282023%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Imaging-based%20assessment%20of%20lung%20function%20in%20a%20population%20cooking%20indoors%20with%20biomass%20fuel%3A%20a%20pilot%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abhilash%20S.%22%2C%22lastName%22%3A%22Kizhakke%20Puliyakote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%20M.%22%2C%22lastName%22%3A%22Stapleton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kumar%22%2C%22lastName%22%3A%22Durairaj%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kesavan%22%2C%22lastName%22%3A%22Karuppusamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geetha%20B.%22%2C%22lastName%22%3A%22Kathiresan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kumaran%22%2C%22lastName%22%3A%22Shanmugam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sirajunnisa%22%2C%22lastName%22%3A%22Abdul%20Rahim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suresh%22%2C%22lastName%22%3A%22Navaneethakrishnan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monalisa%22%2C%22lastName%22%3A%22Bilas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nervana%22%2C%22lastName%22%3A%22Metwali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Jeronimo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kung-Sik%22%2C%22lastName%22%3A%22Chan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junfeng%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prashant%22%2C%22lastName%22%3A%22Nagpal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20M.%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20S.%22%2C%22lastName%22%3A%22Thorne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%20P.%22%2C%22lastName%22%3A%22Comellas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%5D%2C%22abstractNote%22%3A%22This%20pilot%20study%20identi%5Cufb01ed%20environmental%20links%20with%20qCT-based%20lung%20pathologies%20and%20a%20cluster%20of%20biomass%20cooks%20%2833%25%29%20with%20signi%5Cufb01cant%20small%20airways%20disease.%22%2C%22date%22%3A%222023-03-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1152%5C%2Fjapplphysiol.00286.2022%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.physiology.org%5C%2Fdoi%5C%2F10.1152%5C%2Fjapplphysiol.00286.2022%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%228750-7587%2C%201522-1601%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222023-04-24T19%3A58%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22X37ICZNP%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wyszkiewicz%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-31%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BWyszkiewicz%2C%20P.%20V.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15412555.2023.2222831%26%23039%3B%26gt%3BReduced%20Total%20Airway%20Count%20and%20Airway%20Wall%20Tapering%20after%20Three-Years%20in%20Ex-Smokers%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BCOPD%3A%20Journal%20of%20Chronic%20Obstructive%20Pulmonary%20Disease%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B20%26lt%3B%5C%2Fb%26gt%3B%2C%20186%5Cu2013196%20%282023%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reduced%20Total%20Airway%20Count%20and%20Airway%20Wall%20Tapering%20after%20Three-Years%20in%20Ex-Smokers%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paulina%20V.%22%2C%22lastName%22%3A%22Wyszkiewicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maksym%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vedanth%22%2C%22lastName%22%3A%22Desaigoudar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ian%20A.%22%2C%22lastName%22%3A%22Cunningham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20G.%22%2C%22lastName%22%3A%22McCormack%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%20A.%22%2C%22lastName%22%3A%22Abdelrazek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Kirby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Grace%22%2C%22lastName%22%3A%22Parraga%22%7D%5D%2C%22abstractNote%22%3A%22These%20longitudinal%20findings%20suggest%20that%20the%20evaluation%20of%20CT%20airway%20remodeling%20may%20be%20a%20useful%20clinical%20tool%20for%20predicting%20disease%20progression%20and%20managing%20COPD.%22%2C%22date%22%3A%222023-12-31%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1080%5C%2F15412555.2023.2222831%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15412555.2023.2222831%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221541-2555%2C%201541-2563%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222023-07-05T18%3A42%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22BQXFW4WQ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Alkhanfar%20et%20al.%22%2C%22parsedDate%22%3A%222022-04-07%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BAlkhanfar%2C%20D.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fopenres.ersjournals.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1183%5C%2F23120541.00503-2021%26%23039%3B%26gt%3BSevere%20pulmonary%20hypertension%20associated%20with%20lung%20disease%20is%20characterised%20by%20a%20loss%20of%20small%20pulmonary%20vessels%20on%20quantitative%20CT%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BERJ%20Open%20Res%26lt%3B%5C%2Fi%26gt%3B%2000503%5Cu201302021%20%282022%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F23120541.00503-2021%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F23120541.00503-2021%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Severe%20pulmonary%20hypertension%20associated%20with%20lung%20disease%20is%20characterised%20by%20a%20loss%20of%20small%20pulmonary%20vessels%20on%20quantitative%20CT%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dheyaa%22%2C%22lastName%22%3A%22Alkhanfar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousef%22%2C%22lastName%22%3A%22Shahin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faisal%22%2C%22lastName%22%3A%22Alandejani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krit%22%2C%22lastName%22%3A%22Dwivedi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samer%22%2C%22lastName%22%3A%22Alabed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Johns%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Allan%22%2C%22lastName%22%3A%22Lawrie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22AA%20Roger%22%2C%22lastName%22%3A%22Thompson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%20MK%22%2C%22lastName%22%3A%22Rothman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juerg%22%2C%22lastName%22%3A%22Tschirren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%20M%22%2C%22lastName%22%3A%22Uthoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Condliffe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jim%20M%22%2C%22lastName%22%3A%22Wild%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20G%22%2C%22lastName%22%3A%22Kiely%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20J%22%2C%22lastName%22%3A%22Swift%22%7D%5D%2C%22abstractNote%22%3A%22Patients%20with%20PH-ILD%20had%20significantly%20reduced%20small%20pulmonary%20blood%20vessel%20volume%2C%20compared%20to%20PH-COPD%5C%2Femphysema.%20Higher%20mortality%20was%20identified%20in%20patients%20with%20lower%20small%20pulmonary%20vessel%20volume.%20Patients%20with%20severe%20PH-CLD%2C%20regardless%20of%20aetiology%2C%20have%20lower%20small%20pulmonary%20vessel%20volume%20compared%20to%20patients%20with%20mild%5Cu2013moderate%20PH-CLD%2C%20and%20this%20is%20associated%20with%20a%20higher%20mortality.%22%2C%22date%22%3A%222022-04-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1183%5C%2F23120541.00503-2021%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fopenres.ersjournals.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1183%5C%2F23120541.00503-2021%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222312-0541%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%2C%2277SENTSX%22%5D%2C%22dateModified%22%3A%222024-02-21T22%3A39%3A10Z%22%7D%7D%2C%7B%22key%22%3A%22LE7BLBFZ%22%2C%22library%22%3A%7B%22id%22%3A4835300%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vameghestahbanati%20et%20al.%22%2C%22parsedDate%22%3A%222024-02-29%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BVameghestahbanati%2C%20M.%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fjournals.physiology.org%5C%2Fdoi%5C%2F10.1152%5C%2Fjapplphysiol.00694.2022%26%23039%3B%26gt%3BAirway%20tree%20caliber%20heterogeneity%20and%20airflow%20obstruction%20among%20older%20adults%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BJournal%20of%20Applied%20Physiology%26lt%3B%5C%2Fi%26gt%3B%20japplphysiol.00694.2022%20%282024%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1152%5C%2Fjapplphysiol.00694.2022%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1152%5C%2Fjapplphysiol.00694.2022%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Airway%20tree%20caliber%20heterogeneity%20and%20airflow%20obstruction%20among%20older%20adults%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Motahareh%22%2C%22lastName%22%3A%22Vameghestahbanati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leina%22%2C%22lastName%22%3A%22Kingdom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20A.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Kirby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norrina%20B.%22%2C%22lastName%22%3A%22Allen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elsa%22%2C%22lastName%22%3A%22Angelini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Bertoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qutayba%22%2C%22lastName%22%3A%22Hamid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20C.%22%2C%22lastName%22%3A%22Hogg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20R.%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Laine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Maltais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erin%20D.%22%2C%22lastName%22%3A%22Michos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Coralynn%22%2C%22lastName%22%3A%22Sack%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Don%22%2C%22lastName%22%3A%22Sin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%20E.%22%2C%22lastName%22%3A%22Watson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Artur%22%2C%22lastName%22%3A%22Wysoczanksi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Couper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MeiLan%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prescott%22%2C%22lastName%22%3A%22Woodruff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wan%20C.%22%2C%22lastName%22%3A%22Tan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Bourbeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Graham%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20M.%22%2C%22lastName%22%3A%22Smith%22%7D%5D%2C%22abstractNote%22%3A%22Among%20older%20adults%2C%20airway%20tree%20caliber%20heterogeneity%20was%20associated%20with%20airflow%20obstruction%20and%20COPD%20at%20baseline%20but%20was%20not%20associated%20with%20longitudinal%20changes%20in%20spirometry.%22%2C%22date%22%3A%222024-02-29%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1152%5C%2Fjapplphysiol.00694.2022%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.physiology.org%5C%2Fdoi%5C%2F10.1152%5C%2Fjapplphysiol.00694.2022%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%228750-7587%2C%201522-1601%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KPUFPHHZ%22%5D%2C%22dateModified%22%3A%222024-03-06T22%3A24%3A18Z%22%7D%7D%5D%7D
1.
Chaudhary, M. F. A. et al. Predicting severe chronic obstructive pulmonary disease exacerbations using quantitative CT: a retrospective model development and external validation study. The Lancet Digital Health 5, e83–e92 (2023).
1.
Woodruff, P. G. et al. Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function. New England Journal of Medicine 374, 1811–1821 (2016).
1.
Wang, J. M., Ram, S., Labaki, W. W., Han, M. K. & Galbán, C. J. CT-Based Commercial Software Applications: Improving Patient Care Through Accurate COPD Subtyping. Int J Chron Obstruct Pulmon Dis 17, 919–930 (2022).
1.
Hammond, E. et al. Comparison of Low and Ultra-Low Dose Computed Tomography Protocols For Quantitative Lung and Airway Assessment. Med Phys 44, 4747–4757 (2017).
1.
Motahari, A. et al. Repeatability of Pulmonary Quantitative CT Measurements in COPD. Am J Respir Crit Care Med rccm.202209-1698PP (2023) http://doi.org/10.1164/rccm.202209-1698PP.
1.
Almuhanna, A. et al. Mucus plugging is associated with systemic inflammation in COPD. European Respiratory Journal 66, (2025).
1.
Armstrong, H. F. et al. Lung function, percent emphysema, and QT duration: The Multi-Ethnic Study of Atherosclerosis (MESA) lung study. Respir Med 123, 1–7 (2017).
1.
Begum, F. et al. Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study. PLOS ONE 11, e0164134 (2016).
1.
Beiko, T. et al. Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis 4, 204–216 (2017).
1.
Choi, S. et al. Differentiation of quantitative CT imaging phenotypes in asthma versus COPD. BMJ Open Respiratory Research 4, e000252 (2017).
1.
Cosentino, J. et al. Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc 13, 1483–1489 (2016).
1.
Dilger, S. K. et al. Improved pulmonary nodule classification utilizing quantitative lung parenchyma features. JMI 2, 041004 (2015).
1.
Tran, C. et al. Luminal mucus plugs are spatially associated with airway wall thickening in severe COPD and asthma: A single-centered, retrospective, observational study. Respiratory Medicine 202, 106982 (2022).
1.
Smith, B. M. et al. Human airway branch variation and chronic obstructive pulmonary disease. Proceedings of the National Academy of Sciences 115, E974–E981 (2018).
1.
Washko, G. R., Coxson, H. O., O'Donnell, D. E. & Aaron, S. D. CT imaging of chronic obstructive pulmonary disease: insights, disappointments, and promise. The Lancet Respiratory Medicine 5, 903–908 (2017).
1.
Belchi, F. et al. Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease. Sci Rep 8, 5341 (2018).
1.
Bhatt, S. P. et al. Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction: authors' response. Thorax 69, 1147–1148 (2014).
1.
Ostridge, K. et al. Using Novel Computed Tomography Analysis to Describe the Contribution and Distribution of Emphysema and Small Airways Disease in Chronic Obstructive Pulmonary Disease. Annals ATS 16, 990–997 (2019).
1.
Gompelmann, D. et al. The minimal important difference for target lobe volume reduction after endoscopic valve therapy. Int J Chron Obstruct Pulmon Dis 13, 465–472 (2018).
1.
Yablonskiy, D. A. Air Trapping - Insights from CT and In Vivo Lung Morphometry with Hyperpolarized 3He MRI. American Thoracic Society International Conference Meetings Abstracts American Thoracic Society International Conference Meetings Abstracts.
1.
de Oliveira, H. G. et al. Combined Bone Marrow‐Derived Mesenchymal Stromal Cell Therapy and One‐Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial. Stem Cells Transl Med 6, 962–969 (2017).
1.
Lo Cascio, C. M. et al. Percent Emphysema and Daily Motor Activity Levels in the General Population. Chest 151, 1039–1050 (2017).
1.
Oelsner, E. C. et al. Association between emphysema-like lung on cardiac computed tomography and mortality in persons without airflow obstruction: a cohort study. Ann Intern Med 161, 863–873 (2014).
1.
Smith, B. M. et al. Not all measures of hyperinflation are created equal: lung structure and clinical correlates of gas trapping and hyperexpansion in COPD: the Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. Chest 145, 1305–1315 (2014).
1.
Martinez, C. H. et al. Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS. Am J Respir Crit Care Med 195, 464–472 (2017).
1.
Newell, J. D., Sieren, J. & Hoffman, E. A. Development of quantitative computed tomography lung protocols. J Thorac Imaging 28, 266–271 (2013).
1.
McAllister, D. et al. Pulmonary Function is Associated with Distal Aortic Calcium, not Proximal Aortic Distensibility. MESA Lung Study. COPD 8, 71–78 (2011).
1.
Han, M. K. et al. Prevalence and clinical correlates of bronchoreversibility in severe emphysema. Eur Respir J 35, 1048–1056 (2010).
1.
Martinez, F. J. et al. Sex differences in severe pulmonary emphysema. AM.REV.RESPIR.DIS. 176, 243–252 (2007).
1.
Burkart, K. M. et al. APOM and High-Density Lipoprotein are associated with Lung Function and Percent Emphysema. Eur Respir J 43, 1003–1017 (2014).
1.
Powell, R. et al. Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study. Thorax 68, 634–642 (2013).
1.
Barr, R. G. et al. Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling. N Engl J Med 362, 217–227 (2010).
1.
Krachman, S. L. et al. Effect of Emphysema Severity on the Apnea-Hypopnea Index in Smokers with Obstructive Sleep Apnea. Ann Am Thorac Soc 13, 1129–1135 (2016).
1.
Parikh, M. A. et al. Angiotensin-Converting Inhibitors and Angiotensin II Receptor Blockers and Longitudinal Change in Percent Emphysema on Computed Tomography. The Multi-Ethnic Study of Atherosclerosis Lung Study. Ann Am Thorac Soc 14, 649–658 (2017).
1.
Xu, Y., Sonka, M., McLennan, G., Guo, J. & Hoffman, E. A. MDCT-based 3-D texture classification of emphysema and early smoking related lung pathologies. IEEE Trans Med Imaging 25, 464–475 (2006).
1.
Zach, J. A. et al. Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol 47, 596–602 (2012).
1.
Sieren, J. P. et al. Reference standard and statistical model for intersite and temporal comparisons of CT attenuation in a multicenter quantitative lung study. Med Phys 39, 5757–5767 (2012).
1.
Putman, R. K. et al. Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA 315, 672–681 (2016).
1.
Xu, Y., Sonka, M., McLennan, G., Guo, J. & Hoffman, E. Sensitivity and specificity of 3-D texture analysis of lung parenchyma is better than 2-D for discrimination of lung pathology in stage 0 COPD. 5746, 474–485 (2005).
1.
Hueper, K. et al. Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study. Am J Respir Crit Care Med 192, 570–580 (2015).
1.
Kim, V. et al. Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study. Respiratory Research 15, 52 (2014).
1.
Iyer, K. S., Grout, R. W., Zamba, G. K. & Hoffman, E. A. Repeatability and Sample Size Assessment Associated with Computed Tomography-Based Lung Density Metrics. Chronic Obstr Pulm Dis 1, 97–104 (2014).
1.
Chen-Mayer, H. H. et al. Standardizing CT lung density measure across scanner manufacturers. Med Phys 44, 974–985 (2017).
1.
Moslemi, A. et al. Quantitative CT Lung Imaging and Machine Learning Improves Prediction of Emergency Room Visits and Hospitalizations in COPD. Acad Radiol S1076-6332(22)00311–7 (2022) http://doi.org/10.1016/j.acra.2022.05.009.
1.
Makimoto, K. et al. Comparison of Feature Selection Methods and Machine Learning Classifiers for Predicting Chronic Obstructive Pulmonary Disease Using Texture-Based CT Lung Radiomic Features. Acad Radiol S1076-6332(22)00412–3 (2022) http://doi.org/10.1016/j.acra.2022.07.016.
1.
Kizhakke Puliyakote, A. S. et al. Imaging-based assessment of lung function in a population cooking indoors with biomass fuel: a pilot study. Journal of Applied Physiology 134, 710–721 (2023).
1.
Wyszkiewicz, P. V. et al. Reduced Total Airway Count and Airway Wall Tapering after Three-Years in Ex-Smokers. COPD: Journal of Chronic Obstructive Pulmonary Disease 20, 186–196 (2023).
1.
Alkhanfar, D. et al. Severe pulmonary hypertension associated with lung disease is characterised by a loss of small pulmonary vessels on quantitative CT. ERJ Open Res 00503–02021 (2022) http://doi.org/10.1183/23120541.00503-2021.
1.
Vameghestahbanati, M. et al. Airway tree caliber heterogeneity and airflow obstruction among older adults. Journal of Applied Physiology japplphysiol.00694.2022 (2024) http://doi.org/10.1152/japplphysiol.00694.2022.