Asthma

Select peer-reviewed papers:
Asthma & VIDA’s quantitative CT (QCT) analysis.

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Svenningsen, S. et al. Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-Controlled Trial. Am J Respir Crit Care Med 208, 995–997 (2023).
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Leung, C. et al. A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma. Am J Respir Crit Care Med (2023) http://doi.org/10.1164/rccm.202305-0802OC.
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Dunican, E. M. et al. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest 128, 997–1009 (2018).
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Choi, S. et al. Differentiation of quantitative CT imaging phenotypes in asthma versus COPD. BMJ Open Respiratory Research 4, e000252 (2017).
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Trivedi, A. et al. "Using Imaging as a Biomarker for Asthma". J Allergy Clin Immunol 139, 1–10 (2017).
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Herth, F. J. F. et al. The Modern Art of Reading Computed Tomography Images of the Lungs: Quantitative CT. Respiration 95, 8–17 (2018).
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Witt, C. A. et al. Longitudinal changes in airway remodeling and air trapping in severe asthma. Acad Radiol 21, 986–993 (2014).
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Choi, S. et al. Registration-based assessment of regional lung function via volumetric CT images of normal subjects vs. severe asthmatics. J Appl Physiol (1985) 115, 730–742 (2013).
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Donohue, K. M. et al. Asthma and lung structure on computed tomography: the Multi-Ethnic Study of Atherosclerosis Lung Study. J Allergy Clin Immunol 131, 361-368.e1–11 (2013).
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Busacker, A. et al. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest 135, 48–56 (2009).
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Jarjour, N. N. et al. Severe Asthma. Am J Respir Crit Care Med 185, 356–362 (2012).
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Cosentino, J. et al. Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc 13, 1483–1489 (2016).
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Reinhardt, J., D’Souza, N. & Hoffman, E. Intra-Thoracic Airway Measurement: EmphEx Vivo Validation. (1997).
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Reinhardt, J., Park, W., Hoffman, E. & Sonka, M. Intrathoracic airway wall detection using graph search and scanner PSF information. in Medical Imaging (1997). http://doi.org/10.1117/12.274033.
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Nordenmark, L. H., Griffiths, J. M. & Parnes, J. R. Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma. (2023).
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Moslemi, A. et al. Differentiating COPD and asthma using quantitative CT imaging and machine learning. Eur Respir J 60, 2103078 (2022).